Ferroptosis Regulator Information

General Information of the Ferroptosis Regulator (ID: REG10041)
Regulator Name Autophagy-related protein 13 (ATG13)
Synonyms
KIAA0652
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Gene Name ATG13
Gene ID 9776
Regulator Type Protein coding
Uniprot ID O75143
Sequence
METDLNSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPE
VTHEAKKALAGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNR
LSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLSGLGEGFQTVRVGTVGTPV
GTITLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAGEDTGV
IYPSVEDSQEVCTTSFSTSPPSQLSSSRLSYQPAALGVGSADLAYPVVFAAGLNATHPHQ
LMVPGKEGGVPLAPNQPVHGTQADQERLATCTPSDRTHCAATPSSSEDTETVSNSSEGRA
SPHDVLETIFVRKVGAFVNKPINQVTLTSLDIPFAMFAPKNLELEDTDPMVNPPDSPETE
SPLQGSLHSDGSSGGSSGNTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLS
IDIGAQSMAEDLDSLPEKLAVHEKNVREFDAFVETLQ

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Family ATG13 family
Function
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

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HGNC ID
HGNC:29091
KEGG ID hsa:9776
Full List of the Ferroptosis Target of This Regulator and Corresponding Disease/Drug Response(s)
ATG13 can regulate the following target(s), and cause disease/drug response(s). You can browse detail information of target(s) or disease/drug response(s).
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Unspecific Target [Unspecific Target]
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis Target of This Regulator [1]
Responsed Disease Fibrosarcoma ICD-11: 2B53
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Autophagy hsa04140
Cell Process Cell ferroptosis
Cell autophagy
In Vitro Model
 mEFs (Mouse embryonic fibroblasts)
HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Response regulation ATG13 and ATG3 are required for ferroptosis-associated lipid ROS accumulation. Ferroptosis is an autophagic cell death process, and NCOA4-mediated ferritinophagy supports ferroptosis by controlling cellular iron homeostasis in fibrosarcoma HT1080 cells.
Fibrosarcoma [ICD-11: 2B53]
 Disease Info 
In total 1 item(s) under this disease
Experiment 1 Reporting the Ferroptosis-centered Disease Response [1]
Target Regulator Autophagy-related protein 13 (ATG13) Protein coding
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Autophagy hsa04140
Cell Process Cell ferroptosis
Cell autophagy
In Vitro Model
 mEFs (Mouse embryonic fibroblasts)
HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Response regulation ATG13 and ATG3 are required for ferroptosis-associated lipid ROS accumulation. Ferroptosis is an autophagic cell death process, and NCOA4-mediated ferritinophagy supports ferroptosis by controlling cellular iron homeostasis in fibrosarcoma HT1080 cells.
References
Ref 1 Ferroptosis is an autophagic cell death process. Cell Res. 2016 Sep;26(9):1021-32. doi: 10.1038/cr.2016.95. Epub 2016 Aug 12.