Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0425)
Name
FIPC-1
Drug Type
Small molecule
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 2 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Fibrosarcoma ICD-11: 2B53
 Disease Info 
Responsed Regulator Protein disulfide-isomerase (P4HB) Suppressor
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
A-375 cells Amelanotic melanoma Homo sapiens CVCL_0132
Response regulation Iron-dependent and competitive protein labeling by FIPC-1 was demonstrated in a quantitative chemoproteomic workflow that identified several saturable protein targets in fibrosarcoma cells, including P4HB and NT5DC2.
Experiment 2 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Fibrosarcoma ICD-11: 2B53
 Disease Info 
Responsed Regulator 5'-nucleotidase domain-containing protein 2 (NT5DC2) Suppressor
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
A-375 cells Amelanotic melanoma Homo sapiens CVCL_0132
Response regulation Iron-dependent and competitive protein labeling by FIPC-1 was demonstrated in a quantitative chemoproteomic workflow that identified several saturable protein targets in fibrosarcoma cells, including P4HB and NT5DC2.
References
Ref 1 Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis. J Am Chem Soc. 2020 Nov 11;142(45):19085-19093. doi: 10.1021/jacs.0c06709. Epub 2020 Oct 30.