Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0413)
| Name |
Quinazolinyl-arylurea derivatives 7J
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| Drug Type |
Small molecule
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Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
| In total 1 item(s) under this Target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Target for Ferroptosis | Suppressor | |||
| Responsed Disease | Bladder cancer | ICD-11: 2C94 | ||
| Pathway Response | Ferroptosis | hsa04216 | ||
| Apoptosis | hsa04210 | |||
| Autophagy | hsa04140 | |||
| Cell Process | Cell ferroptosis | |||
| Cell apoptosis | ||||
| Cell autophagy | ||||
| Cell proliferation | ||||
| In Vitro Model | BEL-7402 cells | Endocervical adenocarcinoma | Homo sapiens | CVCL_5492 |
| MGC-803 cells | Gastric mucinous adenocarcinoma | Homo sapiens | CVCL_5334 | |
| HCT 116 cells | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| HCC827 cells | Lung adenocarcinoma | Homo sapiens | CVCL_2063 | |
| T24 cells | Bladder carcinoma | Homo sapiens | CVCL_0554 | |
| RT4 cells | Bladder carcinoma | Homo sapiens | CVCL_0036 | |
| Response regulation | Compound 7j treatment could trigger three different cell death forms including apoptosis, ferroptosis, and autophagy; which form would occur depended on the concentrations and incubation time of 7j. Ferroptosis and autophagy occurred in the case of higher concentrations combining with extended incubation time through effectively regulating the Sxc-/GPx4/ROS and PI3K/Akt/mTOR/ULK1 pathways, respectively. Compound 7j could be a promising lead for molecular-targeted anti- bladder cancer agents' discovery. | |||