Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0398)
Name
Shuganning injection
Drug Type
Traditional Chinese Medicin
Full List of Ferroptosis Target Related to This Drug
Heme oxygenase 1 (HMOX1)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver/Suppressor
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model SK-BR-3 cells Breast adenocarcinoma Homo sapiens CVCL_0033
MDA-MB-231 cells Breast adenocarcinoma Homo sapiens CVCL_0062
MDA-MB-468 cells Breast adenocarcinoma Homo sapiens CVCL_0419
BT-549 cells Invasive breast carcinoma Homo sapiens CVCL_1092
MCF-10A cells Normal Homo sapiens CVCL_0598
786-O cells Renal cell carcinoma Homo sapiens CVCL_1051
A2780 cells Ovarian endometrioid adenocarcinoma Homo sapiens CVCL_0134
HCT 116 cells Colon carcinoma Homo sapiens CVCL_0291
Hep-G2 cells Hepatoblastoma Homo sapiens CVCL_0027
A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
L-02 cells Endocervical adenocarcinoma Homo sapiens CVCL_6926
WPMY-1 cells Normal Homo sapiens CVCL_3814
U-87MG cells Glioblastoma Homo sapiens CVCL_0022
HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
In Vivo Model
MDA-MB-231 cells resuspended in PBS (2 x 106/100 m1) were injected subcutaneously into bothhind limbsof 4-6 weeks old femalenude mice. A week later, SGNI was administrated byintraperitoneal injectionat a dose of 112.5 mg/kg/3 d.

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Response regulation Shuganning injection (SGNI) induced a ferroptotic cell death of Triple-negative breast cancer (TNBC) cells. Mechanistically, SGNI induced ferroptosis was dependent on HO-1, which promotes intracellular labile iron pool accumulation, and was alleviated by HO-1 knockdown and inhibition by tin protoporphyrin IX.
References
Ref 1 Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells. Phytomedicine. 2021 May;85:153551. doi: 10.1016/j.phymed.2021.153551. Epub 2021 Mar 18.