Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0390)
Name
Robustaflavone 7,5'-dimethyl ether
Drug Type
Small molecule
Full List of Ferroptosis Target Related to This Drug
Long-chain-fatty-acid--CoA ligase 4 (ACSL4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model MCF-7 cells Breast carcinoma Homo sapiens CVCL_0031
Response regulation Molecular docking study indicated that robustaflavone 7,5'-dimethyl ether (8) is a potential strong inhibitor, which induce ferroptosis via down-regulating the expression level of ACSL4 proteins in human breast cancer MCF-7 cells.
References
Ref 1 Cytotoxic effects of the biflavonoids isolated from Selaginella trichoclada on MCF-7 cells and its potential mechanism. Bioorg Med Chem Lett. 2022 Jan 15;56:128486. doi: 10.1016/j.bmcl.2021.128486. Epub 2021 Dec 4.