Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0363)
Name
Fucoidan
Synonyms
(2S,3S,4S,5S,6R)-4,5-Dihydroxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate; Fucoidan - Ascophyllum nodosum; Fucoidan - Alaria; Fucoidan - Ecklonia; Fucoidan - Durvillea; Fucoidan - Sargassum; Fucoidan - Cladosiphon; Fucoidan - Fucus serratus; Fucoidan - Fucus vesiculosus; Fucoidan - Laminaria digitata; Fucoidan - Laminaria japonicia; Fucoidan - Lessonia nigrescens; Fucoidan - Macrocystis pyrifera; Fucoidan - Pelvetia canaliculata; YF01606; YF09360; YF09361; YF09362; YF09363; YF57714; YF145109; YF146833; YF146834; YF153483; YF157138; YF157165; YF157166; YF157167; Fucoidan - Ascophyllum nodosum, analytical grade

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Structure
Formula
C7H14O7S
IUPAC Name
[(2S,3S,4S,5S,6R)-4,5-dihydroxy-2,6-dimethyloxan-3-yl] hydrogen sulfate
Canonical SMILES
CC1C(C(C(C(O1)C)OS(=O)(=O)O)O)O
InChI
InChI=1S/C7H14O7S/c1-3-5(8)6(9)7(4(2)13-3)14-15(10,11)12/h3-9H,1-2H3,(H,10,11,12)/t3-,4+,5-,6+,7-/m1/s1
InChIKey
NLMDZXKCTWKRSQ-IBISWUOJSA-N
PubChem CID
92023653
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Intracerebral hemorrhage ICD-11: 8B00
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Glutathione metabolism hsa00480
Cell Process Cell ferroptosis
In Vitro Model ARPE-19 cells Normal Homo sapiens CVCL_0145
Omm1 cells Uveal melanoma Homo sapiens CVCL_6939
SH-SY5Y cells Neuroblastoma Homo sapiens CVCL_0019
HT22 cells Normal Mus musculus CVCL_0321
Response regulation Iron-dependent oxidative stress (ferroptosis) is a main hallmark of retinal and brain diseases, including hemorrhage. Fucoidans can abrogate the decrease in the protein levels of the antioxidant enzyme GPX4 that is crucial for ferroptosis.
References
Ref 1 Evaluation of the Effects of Fucoidans from Fucus Species and Laminaria hyperborea against Oxidative Stress and Iron-Dependent Cell Death. Mar Drugs. 2021 Sep 29;19(10):557. doi: 10.3390/md19100557.