Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0357)
| Name |
3,5-bis((E)-2-fluorobenzylidene)piperidin-4-one hydrochloride
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| Synonyms |
EF24; 342808-40-6; 3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone; 3,5-bis((E)-2-fluorobenzylidene)piperidin-4-one hydrochloride; (3E,5E)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one;hydrochloride
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| Structure |
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3D MOL
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| Formula |
C19H16ClF2NO
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| IUPAC Name |
(3E,5E)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one;hydrochloride
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| Canonical SMILES |
C1C(=CC2=CC=CC=C2F)C(=O)C(=CC3=CC=CC=C3F)CN1.Cl
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| InChI |
InChI=1S/C19H15F2NO.ClH/c20-17-7-3-1-5-13(17)9-15-11-22-12-16(19(15)23)10-14-6-2-4-8-18(14)21;/h1-10,22H,11-12H2;1H/b15-9+,16-10+;
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| InChIKey |
ILMJCEBAMHGBAA-XETSTSIRSA-N
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| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Heme oxygenase 1 (HMOX1)
| In total 1 item(s) under this Target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Target for Ferroptosis | Driver/Suppressor | |||
| Responsed Disease | Osteosarcoma | ICD-11: 2B51 | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| Cell Process | Cell ferroptosis | |||
| Cell proliferation | ||||
| In Vitro Model | U2OS cells | Osteosarcoma | Homo sapiens | CVCL_0042 |
| SAOS-2 cells | Osteosarcoma | Homo sapiens | CVCL_0548 | |
| Response regulation | 3,5-bis((E)-2-fluorobenzylidene)piperidin-4-one hydrochloride (EF24) upregulated HMOX1 to suppress GPX4 expression to induce ferroptosis by increasing MDA level, ROS level and intracellular ferric ion level. Thus, EF24 might serve as a potential agent for the treatment of HMOX1-positive osteosarcoma patients. | |||