Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0356)
Name
2-Imino-6-methoxy-2H-chromene-3-carbothioamide
Synonyms
2-Imino-6-methoxy-2H-chromene-3-carbothioamide; 2-imino-6-methoxychromene-3-carbothioamide; NSC684971; 71796-75-3; CHEMBL2004669; DTXSID20356657; STL171476; AKOS003794097; NSC-684971; NCI60_030552; 2-imino-6-methoxy-chromene-3-carbothioamide; 2-imino-6-methoxychromene-3-carboximidothioic acid; AH-034/06206012

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Structure
Formula
C11H10N2O2S
IUPAC Name
2-imino-6-methoxychromene-3-carbothioamide
Canonical SMILES
COC1=CC2=C(C=C1)OC(=N)C(=C2)C(=S)N
InChI
InChI=1S/C11H10N2O2S/c1-14-7-2-3-9-6(4-7)5-8(11(13)16)10(12)15-9/h2-5,12H,1H3,(H2,13,16)
InChIKey
LUCOUNTXDLWPQS-UHFFFAOYSA-N
PubChem CID
828049
Full List of Ferroptosis Target Related to This Drug
Cystine/glutamate transporter (SLC7A11)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Colorectal cancer ICD-11: 2B91
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
mTOR signaling pathway hsa04150
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model DLD-1 cells Colon adenocarcinoma Homo sapiens CVCL_0248
HCT 116 cells Colon carcinoma Homo sapiens CVCL_0291
In Vivo Model
Five-week-old female BALB/c nude mice were purchased from Beijing Weitong Lihua Experimental Animal Technical Co., Ltd. (Beijing, China). The mice were randomly assigned to the treatment and control groups until the tumor size reached approximately 100 mm3. The mice in the treatment group were injected with 0.174 mg/mL IMCA (100 uL), and those in the control group were injected with an equal volume of normal saline. The nude mice were euthanized, and samples were obtained from their tumor, heart, hepar, kidney, and blood after 33 days of IMCA treatment.

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Response regulation 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA) significantly induced the ferroptosis of colorectal cancer cells. Mechanistically, IMCA downregulated the expression of SLC7A11 and decreased the contents of cysteine and glutathione, which resulted in reactive oxygen species accumulation and ferroptosis.
References
Ref 1 IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer. Oxid Med Cell Longev. 2020 Apr 3;2020:1675613. doi: 10.1155/2020/1675613. eCollection 2020.