Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0298)
| Name |
Capsiate
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| Synonyms |
capsiate; 205687-01-0; (E)-4-Hydroxy-3-methoxybenzyl 8-methylnon-6-enoate; (4-hydroxy-3-methoxyphenyl)methyl (E)-8-methylnon-6-enoate; PX8I7HG5I3; (4-hydroxy-3-methoxyphenyl)methyl (6E)-8-methylnon-6-enoate; Capsiate Natura; (6E)-8-METHYL-6-NONENOIC ACID (4-HYDROXY-3-METHOXYPHENYL)METHYL ESTER; UNII-PX8I7HG5I3; SCHEMBL1585964; DTXSID20174575; CHEBI:134190; ZICNYIDDNJYKCP-SOFGYWHQSA-N; HY-N8377; vanillyl (6E)-8-methylnon-6-enoate; vanillyl trans-8-methyl-non-6-enoate; C-255; CS-0143769; C20203; E88102; 4-Hydroxy-3-methoxybenzyl 8-methyl-6-nonenoate; (E)-4-Hydroxy-3-methoxybenzyl8-methylnon-6-enoate; Q27286800; (4-hydroxy-3-methoxyphenyl)methyl (E)-8-methylnon-6-enoate.; 6-Nonenoic acid, 8-methyl-, (4-hydroxy-3-methoxyphenyl)methyl ester, (E)-; 6-nonenoic acid, 8-methyl-, (4-hydroxy-3-methoxyphenyl)methyl ester, (6E)-
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| Structure |
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| Formula |
C18H26O4
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| IUPAC Name |
(4-hydroxy-3-methoxyphenyl)methyl (E)-8-methylnon-6-enoate
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| Canonical SMILES |
CC(C)C=CCCCCC(=O)OCC1=CC(=C(C=C1)O)OC
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| InChI |
InChI=1S/C18H26O4/c1-14(2)8-6-4-5-7-9-18(20)22-13-15-10-11-16(19)17(12-15)21-3/h6,8,10-12,14,19H,4-5,7,9,13H2,1-3H3/b8-6+
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| InChIKey |
ZICNYIDDNJYKCP-SOFGYWHQSA-N
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| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
| In total 1 item(s) under this Target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | ||||
| Target for Ferroptosis | Suppressor | ||||
| Responsed Disease | Ischemia/reperfusion injury | ICD-11: DB98 | |||
| Responsed Regulator | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Suppressor | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Ferroptosis | hsa04216 | ||||
| Cell Process | Cell ferroptosis | ||||
| In Vitro Model | mSIOs (Mouse small intestinal organoids) | ||||
| In Vivo Model |
Six- to eight-week-old specific pathogen-free male C57BL/6 mice were purchased from the animal center of Nanfang Hospital of Southern Medical University (Guangzhou, China). The mice were anesthetized with isoflurane. A noninvasive microvascular artery clip was placed on the superior mesenteric artery (SMA) for 60 min, and the clip was removed for reperfusion for 2 hours. During the study period, body temperature was maintained at 37 with a heating pad, and liquid resuscitation was performed by subcutaneous injection with 0.5 ml of physiological saline immediately after reperfusion.
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| Response regulation | The gut microbiota metabolite capsiate enhances Gpx4 expression and inhibits ferroptosis by activating TRPV1 in intestinal ischemia/reperfusion (I/R) injury, providing a potential avenue for the management of intestinal ischemia/reperfusion (I/R) injury. | ||||