Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0280)
Name
moracin N
Synonyms
moracin N; CHEMBL465881; 5-[6-hydroxy-5-(3-methylbut-2-enyl)-1-benzofuran-2-yl]benzene-1,3-diol; 135248-05-4; 5-[6-hydroxy-5-(3-methylbut-2-en-1-yl)-1-benzofuran-2-yl]benzene-1,3-diol; SCHEMBL6822289; CHEBI:174237; WBSCSIABHGPAMC-UHFFFAOYSA-N; DTXSID501318704; BDBM50251014; HY-N11849; 1,3-benzenediol, 5-[6-hydroxy-5-(3-methyl-2-butenyl)-2-benzofuranyl]-; CS-0880943; 2-(3,5-Dihydroxyphenyl)-6-hydroxy-5-prenylbenzofuran; 5-[6-hydroxy-5-(3-methylbut-2-enyl)-1-benzouran-2-yl]benzene-1,3-diol; InChI=1/C19H18O4/c1-11(2)3-4-12-5-13-8-18(23-19(13)10-17(12)22)14-6-15(20)9-16(21)7-14/h3,5-10,20-22H,4H2,1-2H

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Structure
Formula
C19H18O4
IUPAC Name
5-[6-hydroxy-5-(3-methylbut-2-enyl)-1-benzofuran-2-yl]benzene-1,3-diol
Canonical SMILES
CC(=CCC1=C(C=C2C(=C1)C=C(O2)C3=CC(=CC(=C3)O)O)O)C
InChI
InChI=1S/C19H18O4/c1-11(2)3-4-12-5-13-8-18(23-19(13)10-17(12)22)14-6-15(20)9-16(21)7-14/h3,5-10,20-22H,4H2,1-2H3
InChIKey
WBSCSIABHGPAMC-UHFFFAOYSA-N
PubChem CID
641376
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Nervous system disease ICD-11: 8E7Z
 Disease Info 
Pathway Response Glutathione metabolism hsa00480
Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT22 cells Normal Mus musculus CVCL_0321
Response regulation Moracin N was a good ferroptosis inhibitor in Neurodegenerative diseases. The neuroprotective mechanisms of moracin N included inhibition of glutathione depletion, glutathione peroxidase 4 (GPx4) inactivation, reactive oxygen species (ROS) overproduction and iron accumulation, as well as improvement of intracellular antioxidant enzyme activities.
References
Ref 1 Identification of prenylated phenolics in mulberry leaf and their neuroprotective activity. Phytomedicine. 2021 Sep;90:153641. doi: 10.1016/j.phymed.2021.153641. Epub 2021 Jul 3.