Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0272)
| Name |
Punicic Acid
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| Synonyms |
Punicic acid; Trichosanic acid; 544-72-9; Trichosanoic acid; (9Z,11E,13Z)-octadeca-9,11,13-trienoic acid; 9-cis,11-trans,13-cis-octadecatrienoic acid; cis-9,trans-11,cis-13-Octadecatrienoic acid; UNII-VFQ03H211O; VFQ03H211O; 9,11,13-Octadecatrienoic acid, (9Z,11E,13Z)-; 9,11,13-Octadecatrienoic acid, (Z,Z,E)-; cis,trans,cis-9,11,13-Octadecatrienoic acid; 9Z,11E,13Z-octadeca-9,11,13-trienoic acid; 9(Z),11(E),13(Z)-OCTADECATRIENOIC ACID; 9c,11t,13c-linolenic acid; CHEBI:8638; DTXSID10897463; Octadeca-9c,11t,13c-triensaeure; 9Z,11E,13Z-octadecatrienoic acid; octadeca-9c,11t,13c-trienoic acid; (9Z,11E,13Z)-octadecatrienoic acid; 9cis,11trans,13cis-octadecatrienoic acid; (Z,E,Z)-octadeca-9,11,13-trienoic acid; cis-9, trans-11, cis-13-octadecatrienoic acid; Punicinic acid; C18:3n-5,7,9; 9c,11t,13c-18:3; C18:3 n-5 cis, 7 trans, 9 cis; Fatty Acid 18:3 n-5; SCHEMBL158967; CHEMBL5205249; CUXYLFPMQMFGPL-BGDVVUGTSA-N; DTXCID801326803; LMFA01030146; PD088520; HY-139066; CS-0179308; C08364; Cis,trans,cis-octadeca-9,11,13-trienoic acid; Q201502
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| Structure |
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| Formula |
C18H30O2
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| IUPAC Name |
(9Z,11E,13Z)-octadeca-9,11,13-trienoic acid
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| Canonical SMILES |
CCCCC=CC=CC=CCCCCCCCC(=O)O
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| InChI |
InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h5-10H,2-4,11-17H2,1H3,(H,19,20)/b6-5-,8-7+,10-9-
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| InChIKey |
CUXYLFPMQMFGPL-BGDVVUGTSA-N
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| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
| In total 2 item(s) under this Target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Responsed Disease | Hypopharyngeal cancer | ICD-11: 2B6D | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| Cell Process | Cell ferroptosis | |||
| In Vitro Model | FaDu cells | Hypopharyngeal squamous cell carcinoma | Homo sapiens | CVCL_1218 |
| HCT 116 cells | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| Response regulation | Punicic acid is highly cytotoxic to HCT-116 colorectal and FaDu hypopharyngeal carcinoma cells grown either in monolayers or as three-dimensional spheroids. It induces significant lipid peroxidation and its effects are prevented by the addition of ferroptosis inhibitors. | |||
| Experiment 2 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| Cell Process | Cell ferroptosis | |||
| In Vitro Model | FaDu cells | Hypopharyngeal squamous cell carcinoma | Homo sapiens | CVCL_1218 |
| HCT 116 cells | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| Response regulation | Punicic acid is highly cytotoxic to HCT-116 colorectal carcinoma and FaDu hypopharyngeal carcinoma cells grown either in monolayers or as three-dimensional spheroids. It induces significant lipid peroxidation and its effects are prevented by the addition of ferroptosis inhibitors. | |||