Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00023)
Name
Hypopharyngeal cancer
ICD
ICD-11: 2B6D
Full List of Target(s) of This Ferroptosis-centered Disease
Unspecific Target
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Responsed Disease Hypopharyngeal carcinoma [ICD-11: 2B6D]
Responsed Drug Punicic Acid Investigative
 Drug Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model FaDu cells Hypopharyngeal squamous cell carcinoma Homo sapiens CVCL_1218
HCT 116 cells Colon carcinoma Homo sapiens CVCL_0291
Response regulation Punicic acid is highly cytotoxic to HCT-116 colorectal and FaDu hypopharyngeal carcinoma cells grown either in monolayers or as three-dimensional spheroids. It induces significant lipid peroxidation and its effects are prevented by the addition of ferroptosis inhibitors.
References
Ref 1 Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells. Nutrients. 2021 Aug 10;13(8):2751. doi: 10.3390/nu13082751.