Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0240)
| Name |
Butyrate
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| Synonyms |
butyrate; butanoate; N-Butyrate; n-butanoate; Butanoic acid, ion(1-); 461-55-2; butanate; 1-butanoate; propanecarboxylate; 1-butyrate; 1-propanecarboxylate; CHEMBL62381; NCGC00167555-01; ethyl,acetate; Sodium; butyrate; C11H23NOS; DTXSID8040432; CHEBI:17968; FERIUCNNQQJTOY-UHFFFAOYSA-M; CH3-[CH2]2-COO(-); BDBM50079401; c0035; PD121533; AB01566831_01; Q55582441
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| Structure |
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| Formula |
C4H7O2-
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| IUPAC Name |
butanoate
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| Canonical SMILES |
CCCC(=O)[O-]
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| InChI |
InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1
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| InChIKey |
FERIUCNNQQJTOY-UHFFFAOYSA-M
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| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Nuclear receptor coactivator 4 (NCOA4)
| In total 1 item(s) under this Target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Target for Ferroptosis | Driver | |||
| Responsed Disease | Periodontitis | ICD-11: DA0C | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| Cell Process | Cell ferroptosis | |||
| Cell autophagy | ||||
| In Vitro Model | hPDLFs (Human periodontal ligament fibroblasts) | |||
| Response regulation | Periodontitis-level butyrate disrupted iron homeostasis by activation of NCOA4-mediated ferritinophagy, leading to ferroptosis in PDLFs. Butyrate-induced iron accumulation, reactive oxygen species (ROS) generation, glutathione depletion and lipid peroxidation in PDLFs, and the butyrate-induced ferroptosis can be blocked by the lipid peroxide scavenger ferrostatin-1. | |||