Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0201)
Name
D-2-hydroxyglutarate
Synonyms
(R)-2-Hydroxypentanedioic acid; 13095-47-1; (2R)-2-hydroxypentanedioic acid; D-2-Hydroxyglutaric acid; (R)-2-hydroxyglutaric acid; (R)-Hydroxyglutarate; (R)-2-hydroxyglutarate; Pentanedioic acid, 2-hydroxy-, (2R)-; d-alpha-hydroxyglutaric acid; R9UK2G8Y79; 2-Hydroxyglutaric acid, (R)-; CHEMBL1614745; CHEBI:32796; Glutaric acid, 2-hydroxy-, D-; (R)-(-)-2-Hydroxyglutaric acid; Pentanedioic acid, 2-hydroxy-, (R)-; D-2-Hydroxyglutarate; D-Hydroxyglutarate; 2HG; D-a-Hydroxyglutarate; 2-hydroxy-D-Glutarate; (R)-a-Hydroxyglutarate; delta-2-Hydroxyglutarate; D-a-Hydroxyglutaric acid; 2-hydroxy-delta-Glutarate; D-?-Hydroxyglutaric Acid; D-; A-Hydroxyglutaric acid; 2-hydroxy-D-Glutaric acid; (R)-alpha-Hydroxyglutarate; delta-alpha-Hydroxyglutarate; SCHEMBL8032; (R)-a-Hydroxyglutaric acid; UNII-R9UK2G8Y79; delta-2-Hydroxyglutaric acid; (R)-2-hydroxy-Pentanedioate; 2-hydroxy-delta-Glutaric acid; (R)-2-Hydroxypentanedioicacid; (R)-alpha-Hydroxyglutaric acid; delta-alpha-Hydroxyglutaric acid; (R)-alpha-Hydroxyglutaric acid-; (R)-2-hydroxy-Pentanedioic acid; DTXSID80897218; BDBM50361471; AKOS027325193; FD21404; BS-50252; (R)-.ALPHA.-HYDROXYGLUTARIC ACID-; HY-113038; CS-0059411; C01087; EN300-209542; 93397C3E-3CE9-4FEA-A2ED-8F6FA59A1FEA; Q27104222; Z1205493868; 636-67-9

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Structure
Formula
C5H8O5
IUPAC Name
(2R)-2-hydroxypentanedioic acid
Canonical SMILES
C(CC(=O)O)C(C(=O)O)O
InChI
InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)/t3-/m1/s1
InChIKey
HWXBTNAVRSUOJR-GSVOUGTGSA-N
PubChem CID
439391
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Health ICD-11: N.A.
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HEK-293T cells Normal Homo sapiens CVCL_0063
HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
KYSE-170 cells Esophageal squamous cell carcinoma Homo sapiens CVCL_1358
Response regulation Ectopic expression of mutant IDH1 or treatment of cells with cell-permeable D-2-hydroxyglutarate (D-2-HG) promotes the accumulation of lipid reactive oxygen species (ROS) and subsequently ferroptosis. Mechanistically, mutant IDH1 reduces the protein level of the glutathione peroxidase 4 (GPX4).
References
Ref 1 The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019 Oct 7;10(10):755. doi: 10.1038/s41419-019-1984-4.