Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0188)
Name
Sertaconazole
Synonyms
Sertaconazole; 99592-32-2; Sertaconazol [Spanish]; Sertaconazolum [Latin]; Sertaconazol; Sertaconazolum; FI-7045; Sertaconazole [INN]; Demofix; 1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 1-(2-((7-Chlorobenzo[b]thiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; Sertaconazole (INN); CHEBI:83682; 1-(2-((7-Chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; 72W71I16EG; 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 7-Chloro-3-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl)benzo(b)thiophene; 1H-Imidazole, 1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-; 7-Chloro-3-[1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl]benzo[b]thiophene; Sertaconazole [INN:BAN]; BRN 5385663; UNII-72W71I16EG; SR-05000001439; 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole; 1H-Imidazole, 1-[2-[(7-chlorobenzo[b]thien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-; 7-Cloro-3-(1-(2,4-diclorofenil)-2-(1H-imidazol-1-il)etoxi-metil)benzo(b)tiofeno [Spanish]; Prestwick0_001045; Prestwick1_001045; Prestwick2_001045; Prestwick3_001045; SERTACONAZOLE [MI]; (+-)-1-(2,4-Dichloro-beta-((7-chlorobenzo(b)thien-3-yl)methoxy)phenethyl)imidazole; 7-Cloro-3-(1-(2,4-diclorofenil)-2-(1H-imidazol-1-il)etoxi-metil)benzo(b)tiofeno; SCHEMBL66043; BSPBio_000970; SERTACONAZOLE [VANDF]; SPBio_002905; SERTACONAZOLE [WHO-DD]; BPBio1_001068; CHEMBL1201196; DTXSID0048551; JLGKQTAYUIMGRK-UHFFFAOYSA-N; HMS2089M16; BCP12180; HY-B0736; BDBM50051842; DL-208; STL452922; AKOS015850283; AC-6939; DB01153; 1-[2-[(7-chlorobenzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; NCGC00179356-01; NCGC00179356-09; AB00514018; CS-0009631; FT-0631003; FT-0674559; FT-0674560; FT-0674561; D06883; AB00514018-07; AB00514018_08; EN300-6481081; Q3479994; SR-05000001439-1; BRD-A95939040-008-03-3; Z2194031487; 1-[2-[(7-chlorobenzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; nitric acid; SZ

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Status
Approved
Drug Type
Small molecular drug
Structure
Formula
C20H15Cl3N2OS
IUPAC Name
1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
Canonical SMILES
C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl
InChI
InChI=1S/C20H15Cl3N2OS/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22/h1-8,11-12,19H,9-10H2
InChIKey
JLGKQTAYUIMGRK-UHFFFAOYSA-N
PubChem CID
65863
TTD Drug ID
D0O6UZ
Full List of Ferroptosis Target Related to This Drug
Long-chain-fatty-acid--CoA ligase 4 (ACSL4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver
Responsed Disease Nervous system disease ICD-11: 8E7Z
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model LUHMES cells Normal Homo sapiens CVCL_B056
Response regulation Sertaconazole is the most potent ACSL4 inhibitor identified. In addition, sertaconazole significantly reduced lipid peroxidation and ferroptosis in human differentiated dopaminergic neurons (Lund human mesencephalic LUHMES cells), demonstrating that it is a valuable chemical tool for further investigating the role of ACSL4 in nervous system disease.
References
Ref 1 Repositioning of FDA-Approved antifungal agents to interrogate Acyl-CoA synthetase long chain family member 4 (ACSL4) in ferroptosis. Biochem Pharmacol. 2022 Oct;204:115239. doi: 10.1016/j.bcp.2022.115239. Epub 2022 Sep 6.