Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0175)
Name
Juglone
Synonyms
juglone; 481-39-0; 5-Hydroxy-1,4-naphthoquinone; 5-Hydroxy-1,4-naphthalenedione; 5-Hydroxynaphthalene-1,4-dione; Regianin; Nucin; Juglon; Akhnot; Yuglon; C.I. Natural Brown 7; 8-Hydroxy-1,4-naphthoquinone; 5-Hydroxynaphthoquinone; 1,4-NAPHTHALENEDIONE, 5-HYDROXY-; 5-Hydroxy-p-naphthoquinone; C.I. 75500; 1,4-Naphthoquinone, 5-hydroxy-; Juglane; Jugnlon; Iuglon; 1,4-Naphthoquinone, 8-hydroxy-; 5-Hydroxy-1,4-naphthosemiquinone; 5-Hydroxy-1,4-naftochinon; NSC 153189; NSC 622948; 5-hydroxy-1,4-dihydronaphthalene-1,4-dione; JUGLONE CRYSTALLIZED; CHEMBL43612; W6Q80SK9L6; 5-Hydroxy-[1,4]Naphthoquinone; 8-Hydroxy-1,4-naphthalenedione; CHEBI:15794; NCI 2323; NSC34266; NSC153189; NSC622948; NSC-153189; NSC-622948; 481-13-0; 1, 8-hydroxy-; WLN: L66 BV EVJ GQ; Caswell No. 515AA; CCRIS 5423; EINECS 207-567-5; 5-Hydroxy-1,4-naftochinon [Czech]; BRN 1909764; UNII-W6Q80SK9L6; Antibiotic PD7; MFCD00001684; Spectrum_000415; 3b7j; JUGLONE [MI]; Spectrum2_000778; Spectrum3_001228; Spectrum4_001769; Spectrum5_000357; 5-HNQ; SCHEMBL34185; BSPBio_001157; BSPBio_002676; KBioGR_000497; KBioGR_002257; KBioGR_002470; KBioSS_000497; KBioSS_000895; KBioSS_002477; SPECTRUM300038; 4-08-00-02368 (Beilstein Handbook Reference); DivK1c_001026; SPBio_000856; -Hydroxy-1,4-naphthalenedione; DTXSID0031504; BDBM24777; HMS503M13; KBio1_001026; KBio2_000497; KBio2_000895; KBio2_002470; KBio2_003065; KBio2_003463; KBio2_005038; KBio2_005633; KBio2_006031; KBio2_007606; KBio3_000913; KBio3_000914; KBio3_002176; KBio3_002948; 5-hydroxy-naphthalene-1,4-dione; cMAP_000058; NINDS_001026; Bio1_000441; Bio1_000930; Bio1_001419; Bio2_000409; Bio2_000889; HMS1362I19; HMS1792I19; HMS1923G07; HMS1990I19; HMS3403I19; Juglone - CAS 481-39-0; 5-hydroxy-1,4-naphthoquinone, 4; HY-N6949; CCG-40256; NSC-34266; s5512; ZB1862; 5-Hydroxy-1,4-naphthoquinone, 97%; AKOS001576598; 5-Hydroxy-1,4-naphthalenedione, 9CI; CS-W017516; SDCCGMLS-0066542.P001; IDI1_001026; IDI1_002164; SMP1_000168; NCGC00095247-01; NCGC00095247-02; NCGC00095247-03; NCGC00095247-04; NCGC00095247-05; CI 75500; CI-75500; 1,4-dihydro-1,4-dioxo-5-hydroxynaphthalene; AM20040546; FT-0627559; H0286; C03840; EN300-160375; F17689; A827478; A936425; Q900912; SR-05000002406; J-650071; Q-100522; SR-05000002406-1; F0451-0746; InChI=1/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12

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Structure
Formula
C10H6O3
IUPAC Name
5-hydroxynaphthalene-1,4-dione
Canonical SMILES
C1=CC2=C(C(=O)C=CC2=O)C(=C1)O
InChI
InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H
InChIKey
KQPYUDDGWXQXHS-UHFFFAOYSA-N
PubChem CID
3806
Full List of Ferroptosis Target Related to This Drug
Heme oxygenase 1 (HMOX1)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Driver/Suppressor
Responsed Disease Corpus uteri cancer ICD-11: 2C76
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Autophagy hsa04140
Cell Process Cell ferroptosis
Cell autophagy
Cell migration
In Vitro Model Ishikawa cells Endometrial adenocarcinoma Homo sapiens CVCL_2529
Response regulation Juglone as a natural quinone from C. cathayensisgreen peel could exert its anti-cancer activity by inducing iron dependent autophagy and inhibiting the migration of endometrial cancer (EC) cells. Subsequently, Fe2+ accumulation, lipid peroxidation, GSH depletion, the upregulation of HMOX1, and heme degradation to Fe2+ were reported. Juglone was involved in inducing autophagy and inhibiting cell migration and endoplasmic reticulum stress.
References
Ref 1 Juglone, a novel activator of ferroptosis, induces cell death in endometrial carcinoma Ishikawa cells. Food Funct. 2021 Jun 8;12(11):4947-4959. doi: 10.1039/d1fo00790d.