Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0154)
Name
Sodium Selenite
Synonyms
SODIUM SELENITE; Disodium selenite; 10102-18-8; Natriumselenit; Selenious Acid Disodium Salt; Selenious acid, disodium salt; Disodium selenium trioxide; Selenite sodium; disodium;selenite; Sodium selenite anhydrous; CCRIS 1260; HSDB 768; UNII-HIW548RQ3W; EINECS 233-267-9; HIW548RQ3W; Selenious acid, sodium salt (1:2); MFCD00003489; Selenious acid (H2SeO3), disodium salt; DTXSID0032077; CHEBI:48843; NSC-347466; DTXCID8012077; EC 233-267-9; NSC 347466; 10102-18-8(disodiumsalt)7782-82-3(monosodiumsalt); Sodium selenite (JAN); SODIUM SELENITE [JAN]; dinatriumselenit; Natriumselenit [German]; SODIUM SELENITE (EP MONOGRAPH); SODIUM SELENITE [EP MONOGRAPH]; Selenite, Sodium; Selenite, Disodium; NA2630; Selenous Acid Disodium Salt; Aselend; Selenous Acid, Disodium Salt; Sodium-selenite; H2-O3-Se.1/2Na; Aselend (TN); Sodium Selenite,(S); SODIUM SELENITE [MI]; SODIUM SELENITE [HSDB]; CHEMBL112302; SODIUM SELENITE [VANDF]; DISODIUM SELENITE [INCI]; SODIUM SELENITE [WHO-DD]; BVTBRVFYZUCAKH-UHFFFAOYSA-L; SODIUM SELENATE (NA2SEO3); Tox21_202977; SODIUM SELENITE [GREEN BOOK]; AKOS015912461; SODIUM SELENIUM OXIDE(NA2SEO3); Sodium selenite [NA2630] [Poison]; NCGC00260523-01; CAS-10102-18-8; SELENIOUS ACID(H2SEO3), DISODIUM SALT; D10530; SODIUM SELENITE HIGH PURITY GRADE 100G; Q414626

    Click to Show/Hide
Structure
3D MOL
2D MOL
Formula
Na2O3Se
IUPAC Name
disodium;selenite
Canonical SMILES
[O-][Se](=O)[O-].[Na+].[Na+]
InChI
InChI=1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
InChIKey
BVTBRVFYZUCAKH-UHFFFAOYSA-L
PubChem CID
24934
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Glioblastoma ICD-11: 2A00
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model U-87MG cells Glioblastoma Homo sapiens CVCL_GP63
HeLa cells Endocervical adenocarcinoma Homo sapiens CVCL_0030
MCF-7 cells Breast carcinoma Homo sapiens CVCL_0031
PC-3 cells Prostate carcinoma Homo sapiens CVCL_0035
HT-29 cells Colon adenocarcinoma Homo sapiens CVCL_0320
SVG p12 cells Normal Homo sapiens CVCL_3797
A-172 cells Glioblastoma Homo sapiens CVCL_0131
HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
HCT 116 cells Colon carcinoma Homo sapiens CVCL_0291
Response regulation Sodium selenite (SS) down-regulates ferroptosis regulators; solute carrier family 7 member 11 (SLC7A11), glutathione (GSH), and glutathione peroxidase 4 (GPx4), while it up-regulates iron accumulation and lipid peroxidation (LPO) in Glioblastoma.
References
Ref 1 Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite. Transl Oncol. 2020 Nov;13(11):100843. doi: 10.1016/j.tranon.2020.100843. Epub 2020 Aug 15.