Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0143)
Name
L-Homocysteine
Synonyms
L-Homocysteine; homocysteine; 6027-13-0; (s)-2-amino-4-mercaptobutanoic acid; (2S)-2-amino-4-sulfanylbutanoic acid; 2-AMINO-4-MERCAPTO-BUTYRIC ACID; CHEBI:17588; L-2-Amino-4-mercaptobutyric acid; 0LVT1QZ0BA; CHEMBL469662; Hcy; homo-cys; 454-28-4; Homocysteine, L-; Butyric acid, 2-amino-4-mercapto-; MFCD00151320; HCS; Homocysteine (VAN); UNII-0LVT1QZ0BA; (S)-2-Amino-4-mercaptobutyric acid; 2-amino-4-sulfanylbutanoate; NSC-43117; NSC-118376; EINECS 227-891-0; NSC 43117; H-Hcys-OH; NSC 118376; 2-Amino-4-mercaptobutyric acid (VAN); Butyric acid, 2-amino-4-mercapto-, L-; (S)-HOMOCYSTEINE; Butanoic acid, 2-amino-4-mercapto- (VAN); HOMOCYSTEINE [MI]; Butanoic acid, 2-amino-4-mercapto-, (S)-; Epitope ID:143650; SCHEMBL35837; 2-amino-4-mercapto-Butanoate; GTPL5198; DTXSID3041039; 2-amino-4-mercapto-DL-Butyrate; 2-amino-4-mercapto-Butanoic acid; FFFHZYDWPBMWHY-VKHMYHEASA-N; (S)-2-amino-4-mercapto-Butanoate; L-2-amino-4-mercapto-Butyric acid; (s)-2-amino-4-mercaptobutanoicacid; 2-amino-4-mercapto-DL-Butyric acid; BDBM50242405; DL-2-amino-4-mercapto-Butyric acid; L-Homocysteine, >=98.0% (NT); AKOS006272166; (S)-2-amino-4-mercapto-Butanoic acid; CS-W011063; DB04422; FS-6405; HY-W010347; C00155; H-2800; I11579; A832662; Q26992833

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Status
Investigative
Drug Type
Small molecular drug
Structure
Formula
C4H9NO2S
IUPAC Name
(2S)-2-amino-4-sulfanylbutanoic acid
Canonical SMILES
C(CS)C(C(=O)O)N
InChI
InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1
InChIKey
FFFHZYDWPBMWHY-VKHMYHEASA-N
PubChem CID
91552
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Intervertebral disc degeneration ICD-11: FA80
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Apoptosis hsa04210
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell necrosis
In Vitro Model hNPCs (Human nucleus pulposus cells)
In Vivo Model
Thirty male C57BL/6 mice (8 weeks old, average weight 25 g) were divided into three groups. Blank group: Ten mice were fed with normal diet and water. HHcy group: Ten mice were fed with a high Met diet (normal diet with 2% l-methionine). HHcy + Folic Acidrescue group: Ten mice were fed withhigh Met diet (normal diet with 2% l-methionine), and injected with Folic Acid (1.0 umol/kg/d) twice a week two months later. At the beginning of treatment, mice were anesthetized with anintraperitoneal injectionof 0.3% (w/v)pentobarbital sodium(20 uL/g) before surgery and disc degeneration was induced by stabbing the C5-6 and C6-7 discs with a 32G needle.

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Response regulation Homocysteine (Hcy) is an amino acid involved in gene methylation. Hcy upregulates oxidative stress and ferroptosis in the nucleus pulposus via enhancing GPX4 methylation, and is a new contributing factor in intervertebral disc degeneration (IVDD).
References
Ref 1 Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4. Free Radic Biol Med. 2020 Nov 20;160:552-565. doi: 10.1016/j.freeradbiomed.2020.08.029. Epub 2020 Sep 5.