Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0074)
Name
Selenium
Synonyms
7782-49-2; Se; Selenium; Selenium hydride; SELENIUM ATOM; Elemental selenium; Selenium elemental; Selenium, elemental; Selen; Selenium dihydride; Selenium metallicum; SELENIUM POWDER; CI 77805; Dihydrogen monoselenide; C.I. 77805; SELENIUM78; MFCD00134090; Hydrogen selenide, anhydrous; H6241UJ22B; Vandex; Gray selenium; Selenium base; Selenium dust; Colloidal selenium; Selen [Polish]; elenium, elemental; Vandex;; Selenium, metallic; Selenium, colloidal; Caswell No. 732; selenio; Selenium anhydride; Electronic E-2; CCRIS 4250; HSDB 4493; EINECS 231-957-4; UN2658; Hydrogen selenide (H2Se); EPA Pesticide Chemical Code 072001; Selenium Standard: Se @ 1000 microg/mL in 5% HNO3; Selenium Standard: Se @ 10000 microg/mL in 5% HNO3; Selenium AA Standard: Se @ 1000 microg/mL in 5% HNO3; Selenium metal; UNII-H6241UJ22B; HSDB 548; Non-Metals Standard: As, B, P, S, Se, Si, Te @ 100 microg/mL in 5% HCl, tr. HF; Selenium (Powder); EINECS 231-978-9; Selenium shot, 4N; selenium (hexagonal); UN2202; UN3283; selenium (iv) hydride; HYDROGEN SELENID; B-TRAXIM SE; SELENIUM [MI]; SELENIUM [VANDF]; Selenium hydride (SeH2); SELENIUM [MART.]; 34Se; SELENIUM [WHO-DD]; UNII-V91P54KPAM; EC 231-957-4; Selenium, powder, 99+%; Selenium compound, n.o.s.; Selenium powder, -200 mesh; Selenium powder, -325 mesh; SELSAF 2000; HYDROGEN SELENIDE [MI]; Selenium, p.a., 99.5%; Selenium - Se @1000ug/mL; CHEMBL1235891; DTXSID9021261; CHEBI:27568; HSDB 6909; Selenium Nanopowder in aq. media; BUGBHKTXTAQXES-UHFFFAOYSA-N; SELENIUM METALLICUM [HPUS]; SELENIUM, ELEMENTAL [HSDB]; DB11135; NSC-605850; NSC-605851; NSC-605852; N725; Q876; Selenium, pellets, < 5mm, >=99.999%; E1457; FT-0701285; Selenium ingot/button, ~38mm (1.5in) dia; C01529; Selenium - Se @ 1000 microg/g in Hydrocarbon Oil; Selenium powder [UN2658] [Keep away from food]; Selenium shot, amorphous, 1-5mm (0.04-0.20in); Selenium Standard: Se @ 10 microg/mL in 2% HNO3; Selenium, foil, 25x25mm, thickness 3mm, 99.95%; Hydrogen selenide, anhydrous [UN2202] [Poison gas]; S008000000; Selenium, shots, 99.99999% (7N), diameter 2-4 mm; Selenium Standard: Se @ 1000 microg/g in Hydrocarbon Oil; Selenium, pellets, <5 mm, >=99.99% trace metals basis; Selenium, powder, -100 mesh, >=99.5% trace metals basis; Selenium, powder, -100 mesh, 99.99% trace metals basis; Selenium compound, n.o.s. [UN3283] [Poison, Keep away from food]; Selenium, lump, 3 mm max. lump size, weight 100 g, high purity 99.999%; Selenium, lump, 3 mm max. lump size, weight 20 g, high purity 99.999%; Selenium, lump, 3 mm max. lump size, weight 50 g, high purity 99.999%; Selenium, pellets, <5 mm particle size, >=99.999% trace metals basis; Sulfur-Free Selenium Standard: Se @ 1000 microg/g in Hydrocarbon Oil; Selenium shot, amorphous, 2-6mm (0.08-0.2in), Puratronic(R), 99.999% (metals basis); Selenium, powder, 250 max. part. size (micron), purity 99.95%, weight 100 g; Selenium, powder, 250 max. part. size (micron), weight 50 g, purity 99.95%; Selenium, powder, max. particle size 250 micron, weight 200 g, purity 99.95%; Selenium, rod, 99.9999% (6N), diameter 20 mm, length 55 mm, approx. 74g; Selenium, rod, 99.99999% (7N), diameter 20 mm, length 55 mm, approx. 74 g; Se0

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Status
Approved
Drug Type
Small molecular drug
Structure
3D MOL
2D MOL
Formula
Se
IUPAC Name
selenium
Canonical SMILES
[Se]
InChI
InChI=1S/Se
InChIKey
BUGBHKTXTAQXES-UHFFFAOYSA-N
PubChem CID
6326970
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Health ICD-11: N.A.
 Disease Info 
Pathway Response Glutathione metabolism hsa00480
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model mTCs (Mouse T cells)
In Vivo Model
All mice used in this study were 6-12 weeks old on a C57/BL6/J background. WT or T-KO mice were fed with water supplemented with methionine (1 mgl-1, Sigma) or Se-Met (1 mgl-1, Sigma) and maintained on the diets for 4 weeks before experiments. Alternatively, WT mice were fed with selenium-adequate (0.15 mg/kg) and selenium-high (1 mg/kg) diets that were purchased from Envigo and mice were maintained on the diets for 4 weeks before experiments.

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Response regulation The deletion of GPX4 in T cells selectively abrogated TFH cells and germinal center responses in immunized mice. Selenium supplementation enhanced GPX4 expression in T cells, increased TFH cell numbers and promoted antibody responses in immunized mice and young adults after influenza vaccination.
References
Ref 1 Selenium-GPX4 axis protects follicular helper T cells from ferroptosis. Nat Immunol. 2021 Sep;22(9):1127-1139. doi: 10.1038/s41590-021-00996-0. Epub 2021 Aug 19.