Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0071)
Name
Cumene hydroperoxide
Synonyms
CUMENE HYDROPEROXIDE; Cumyl hydroperoxide; 80-15-9; Cumenyl hydroperoxide; Cumolhydroperoxid; Cumolhydroperoxide; 7-Cumyl hydroperoxide; Hydroperoxide, 1-methyl-1-phenylethyl; alpha,alpha-Dimethylbenzyl hydroperoxide; Cument hydroperoxide; 2-hydroperoxypropan-2-ylbenzene; Hydroperoxyde de cumene; Hydroperoxyde de cumyle; Cumeenhydroperoxyde; Kumenylhydroperoxid; Isopropylbenzene hydroperoxide; 7-Hydroperoxykumen; RCRA waste number U096; Hydroperoxide de cumene; Idroperossido di cumene; Idroperossido di cumolo; Percumyl H; 1-Methyl-1-phenylethyl hydroperoxide; CCRIS 3801; HSDB 254; Hyperiz; DTXSID3024869; UNII-PG7JD54X4I; EINECS 201-254-7; PG7JD54X4I; alpha,alpha-Dimethylbenzylhydroperoxide; Trigonox K 80; BRN 1908117; Hydroperoxide, 1-methyl-1-phenylethyl-; CHEBI:78673; Hydroperoxide, alpha,alpha-dimethylbenzyl-; PH 80; alpha-Cumyl hydroperoxide; alpha-Cumene hydroperoxide; LUPEROX CU 80; TRIGONOX K 90; 2-Phenylpropane-2-peroxol; Hydroperoxide, alpha,alpha-dimethylbenzyl; DTXCID404869; EC 201-254-7; 4-06-00-03221 (Beilstein Handbook Reference); .alpha.,.alpha.-Dimethylbenzyl hydroperoxide; cumylhydroperoxide; Hydroperoxide, .alpha.,.alpha.-dimethylbenzyl; Cumene Hydroperoxide (80per cent, Technical grade); Cumolhydroperoxid [German]; Cumeenhydroperoxyde [Dutch]; Kumenylhydroperoxid [Czech]; 7-Hydroperoxykumen [Czech]; Hydroperoxyde de cumene [French]; Hydroperoxyde de cumyle [French]; Idroperossido di cumene [Italian]; Idroperossido di cumolo [Italian]; RCRA waste no. U096; r 239a; isopropyl benzene hydroperoxide; cumyl-hydroperoxide; Trigonox K-95; Trigonox R 239A; KAYACUMENE H; dimethylbenzyl hydroperoxide; TRIGONOX R 239R; .alpha.-Cumyl hydroperoxide; CHP-5; .alpha.-Cumene hydroperoxide; SCHEMBL15251; CHEMBL1518369; SCHEMBL11210695; CHP-158; 2-phenylpropan-2-yl hydroperoxide; CUMENE HYDROPEROXIDE [HSDB]; Tox21_300283; MFCD00002129; STL453641; AKOS015841738; CCG-207896; UN 2116; 2-PHENYL-2-PROPYL HYDROPEROXIDE; CAS-80-15-9; alpha, alpha-dimethylbenzyl hydroperoxide; NCGC00091748-01; NCGC00091748-02; NCGC00091748-03; NCGC00254045-01; Cumene hydroperoxide, technical grade, 80%; C2223; ALPHA,ALPHA-DIMETHYLBENZENE HYDROPEROXIDE; Cumene hydroperoxide, technical, ~80% in cumene; Q414439

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Structure
Formula
C9H12O2
IUPAC Name
2-hydroperoxypropan-2-ylbenzene
Canonical SMILES
CC(C)(C1=CC=CC=C1)OO
InChI
InChI=1S/C9H12O2/c1-9(2,11-10)8-6-4-3-5-7-8/h3-7,10H,1-2H3
InChIKey
YQHLDYVWEZKEOX-UHFFFAOYSA-N
PubChem CID
6629
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Fuchs endothelial corneal dystrophy ICD-11: 9A70
 Disease Info 
Responsed Regulator Peroxiredoxin-1 (PRDX1) Suppressor
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model hPCECs (Human primary corneal endothelial cells)
B4G12-CEnC (Human corneal endothelial cells)
HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Response regulation Cumene hydroperoxide strongly induces lipid peroxidation. Moreover, this can be suppressed by Fer-1 as well as iron chelators such as DFO (not shown). Increased oxidative stress drives the loss of PRDX1 expression and renders CEnCs susceptible to lipid peroxidation in Fuchs' endothelial corneal dystrophy.
References
Ref 1 Peroxiredoxin-1 regulates lipid peroxidation in corneal endothelial cells. Redox Biol. 2020 Feb;30:101417. doi: 10.1016/j.redox.2019.101417. Epub 2019 Dec 30.