General Information of the Disease (ID: DIS00084)
Name
Fuchs endothelial corneal dystrophy
ICD
ICD-11: 9A70
Full List of Target(s) of This Ferroptosis-centered Disease
Unspecific Target
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Responsed Disease Fuchs endothelial corneal dystrophy [ICD-11: 9A70]
Responsed Drug Cumene hydroperoxide Investigative
Responsed Regulator Peroxiredoxin-1 (PRDX1) Suppressor
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model hPCECs (Human primary corneal endothelial cells)
B4G12-CEnC (Human corneal endothelial cells)
HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Response regulation Cumene hydroperoxide strongly induces lipid peroxidation. Moreover, this can be suppressed by Fer-1 as well as iron chelators such as DFO (not shown). Increased oxidative stress drives the loss of PRDX1 expression and renders CEnCs susceptible to lipid peroxidation in Fuchs' endothelial corneal dystrophy.
References
Ref 1 Peroxiredoxin-1 regulates lipid peroxidation in corneal endothelial cells. Redox Biol. 2020 Feb;30:101417. doi: 10.1016/j.redox.2019.101417. Epub 2019 Dec 30.