Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00084)
| Name |
Fuchs endothelial corneal dystrophy
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|---|---|---|---|---|---|
| ICD |
ICD-11: 9A70
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Full List of Target(s) of This Ferroptosis-centered Disease
Unspecific Target
| In total 1 item(s) under this target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | |||
| Responsed Disease | Fuchs endothelial corneal dystrophy [ICD-11: 9A70] | |||
| Responsed Drug | Cumene hydroperoxide | Investigative | ||
| Responsed Regulator | Peroxiredoxin-1 (PRDX1) | Suppressor | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| Cell Process | Cell ferroptosis | |||
| In Vitro Model | hPCECs (Human primary corneal endothelial cells) | |||
| B4G12-CEnC (Human corneal endothelial cells) | ||||
| HT-1080 cells | Fibrosarcoma | Homo sapiens | CVCL_0317 | |
| Response regulation | Cumene hydroperoxide strongly induces lipid peroxidation. Moreover, this can be suppressed by Fer-1 as well as iron chelators such as DFO (not shown). Increased oxidative stress drives the loss of PRDX1 expression and renders CEnCs susceptible to lipid peroxidation in Fuchs' endothelial corneal dystrophy. | |||