Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0069)
Name
Methamphetamine
Synonyms
METHAMPHETAMINE; Metamfetamine; d-Deoxyephedrine; d-Desoxyephedrine; d-Methamphetamine; Methylamphetamine; d-N-Methylamphetamine; Metamphetamine; d-Methylamphetamine; N-Methylamphetamine; d-Phenylisopropylmethylamine; (S)-Methamphetamine; D-1-Phenyl-2-methylaminopropane; Norodin; (S)-Methylamphetamine; (+)-Methylamphetamine; d-(S)-Methamphetamine; Metamfetamina; Metamfetaminum; Methyl-beta-phenylisopropylamine; Desyphed; (+)-N-Methylamphetamine; 537-46-2; (+)-(S)-Deoxyephedrine; (S)-(+)-Deoxyephedrine; L-Methamphetamine; 1-Phenyl-2-methylaminopropane; Metanfetamina; Stimulex; Speed; Meth; S-(+)-Methamphetamine; (2S)-N-methyl-1-phenylpropan-2-amine; (+)-methamphetamine; (S)-N,alpha-Dimethylbenzeneethanamine; D-N,alpha-dimethylphenethylamine; Crank; Methamphetaminum; Crystal Meth; Metamfetamine [INN]; (+)-2-(N-Methylamino)-1-phenylpropane; Metamfetaminum [INN-Latin]; Metamfetamina [INN-Spanish]; Metanfetamina [INN-Spanish]; Methamphetaminum [INN-Latin]; (+)-N,alpha-Dimethylphenethylamine; dextromethamphetamine; D-1-Phenyl-2-methylaminopropan; (+)-N,alpha-Dimethyl-beta-phenylethylamine; Meth (Street Name); N-Methyl-beta-phenylisopropylamine; 1-Phenyl-2-methylamino-propan [German]; (+)-(S)-N-alpha-Dimethylphenethylamine; Metamfetaminum [Latin]; d-1-Phenyl-2-methylaminopropan [German]; 2S-(+)-Methamphetamine; (S)-(+)-Methamphetamine; (alphaS)-N,alpha-dimethylbenzeneethanamine; ICE [Street Name]; N-Methyl-beta-phenylisopropylamin [German]; Crank [Street Name]; Speed [Street Name]; NSC 25115; CHEBI:6809; HSDB 3359; (s)-phenylmethylaminopropane; EINECS 208-668-7; Crystal Meth [Street Name]; NSC-25115; (S)-N,alpha-Dimethylbenzeneethanoamine; UNII-44RAL3456C; (S)-(+)-N,alpha,dimethylphenethylamine; Metamfetamine (INN); Phenethylamine, N,alpha-dimethyl-, (+)-; N-Methyl-1-phenyl-2-propanamine; 44RAL3456C; Benzeneethanamine, N,alpha-dimethyl-, (S)-; Methyl-.beta.-phenylisopropylamine; d-N,.alpha.-Dimethylphenethylamine; Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-; J6.362B; DTXSID8037128; Desoxyephedrine hydrochloride; 1-Phenyl-2-methylamino-propan; Crank (Street Name); ICE (Street Name); Speed (Street Name); N-Methyl-beta-phenylisopropylamin; Metamfetaminum (Latin); Methamphetaminum [JP]; Metanfetamina [Spanish]; Crystal Meth (Street Name); Desyphed hydrochloride; desohyephedrine; Metamfetamine-m; N Methylamphetamine; (+ )-Methylamphetamine; Benzeneethanamine, N,alpha-dimethyl-, (+)-; DEA No. 1105; B40; metamfetamine racemate; Benzeneethanamine, N,.alpha.-dimethyl-, (S)-; Phenethylamine, N,.alpha.-dimethyl-, (S)-(+)-; Epitope ID:178090; intra-venous methamphetamine; Phenethylamine, N,alpha-dimethyl-, (S)-(+)-; Benzeneethanamine,.alpha.-dimethyl-, (S)-; d-N,a-dimethylphenethylamine; METHAMPHETAMINE [MI]; SCHEMBL42615; Phenethylamine,.alpha.-dimethyl-, (S)-(+)-; METHAMPHETAMINE [HSDB]; METAMFETAMINE [WHO-DD]; METHAMPHETAMINE [VANDF]; CHEMBL1201201; DTXCID6017128; WLN: 1MY1&1R -D; N06BA03; N,I+/--Dimethyl-phenethyl amine; Desyphed hydrochloride (Salt/Mix); NSC25115; N-Methyl-1-phenyl-2-propanamine #; BDBM50359499; PDSP1_001404; PDSP1_001405; PDSP2_001388; PDSP2_001389; (+)-N,.alpha.-Dimethylphenethylamine; (S)-N-methyl-1-phenylpropan-2-amine; DB01577; Desoxyephedrine hydrochloride (Salt/Mix); methyl[(2S)-1-phenylpropan-2-yl]amine; Phenethylamine,.alpha.-dimethyl-, (+)-; (+)-(S)-N-.alpha.-Dimethylphenethylamine; Benzeneethanamine,.alpha.-dimethyl-, (+)-; Phenethylamine, N,.alpha.-dimethyl-, (+)-; Benzeneethanamine, N,.alpha.-dimethyl-, (+)-; C07164; D08187; (+)-N,.alpha.-Dimethyl-.beta.-phenylethylamine; Q191924; Phenethylamine, N,alpha-dimethyl-, (S)-(+)- (8CI); Benzeneethanamine, N,alpha-dimethyl-, (alphaS)- (9CI); (+)-N,.alpha.-Dimethylphenethylamine hydrochloride (Salt/Mix)

    Click to Show/Hide
Structure
Formula
C10H15N
IUPAC Name
(2S)-N-methyl-1-phenylpropan-2-amine
Canonical SMILES
CC(CC1=CC=CC=C1)NC
InChI
InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1
InChIKey
MYWUZJCMWCOHBA-VIFPVBQESA-N
PubChem CID
10836
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease HIV Infection ICD-11: 1C60
 Disease Info 
Responsed Regulator Cellular tumor antigen p53 (TP53) Driver
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model BV-2 cells Normal Mus musculus CVCL_0182
Response regulation Methamphetamine (METH) and HIV-1 lead to oxidative stress and their combined effect increases the risk of HIV-associated neurocognitive disorder (HAND), which may be related to the synergistic ferroptotic impairment in microglia. We found that METH and HIV-1 Tat reduced the expression of ferroptotic protein GPX4 and the cell viability and enhanced the expression of P53 and the level of ferrous iron, while the above indices were significantly improved with pretreatment of ferrostatin-1.
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease HIV Infection ICD-11: 1C60
 Disease Info 
Pathway Response Ferroptosis hsa04216
Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model BV-2 cells Normal Mus musculus CVCL_0182
Response regulation Methamphetamine (METH) and HIV-1 lead to oxidative stress and their combined effect increases the risk of HIV-associated neurocognitive disorder (HAND), which may be related to the synergistic ferroptotic impairment in microglia. We found that METH and HIV-1 Tat reduced the expression of ferroptotic protein GPX4 and the cell viability and enhanced the expression of P53 and the level of ferrous iron, while the above indices were significantly improved with pretreatment of ferrostatin-1.
References
Ref 1 NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11. Neurotox Res. 2023 Oct;41(5):398-407. doi: 10.1007/s12640-023-00645-4. Epub 2023 Apr 15.