Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0023)
Name
Carvacrol
Synonyms
CARVACROL; 5-Isopropyl-2-methylphenol; 499-75-2; Antioxine; Isopropyl-o-cresol; 2-p-Cymenol; o-Thymol; Karvakrol; 5-Isopropyl-o-cresol; Isothymol; 2-Hydroxy-p-cymene; p-Cymen-2-ol; Phenol, 2-methyl-5-(1-methylethyl)-; 2-Methyl-5-isopropylphenol; 3-Isopropyl-6-methylphenol; p-Cymene, 2-hydroxy-; 5-Isopropyl-2-methyl-phenol; o-Cresol, 5-isopropyl-; 2-Methyl-5-(1-methylethyl)phenol; 2-Methyl-5-(Propan-2-Yl)Phenol; 6-Methyl-3-isopropylphenol; 1-Hydroxy-2-methyl-5-isopropylbenzene; FEMA No. 2245; 2-methyl-5-propan-2-ylphenol; Phenol, 5-isopropyl-2-methyl-; Cymene-2-ol, p-; Caswell No. 511; Phenol, 3-isopropyl-6-methyl-; 1-Methyl-2-hydroxy-4-isopropylbenzene; CYMOPHENOL; DENTOL; NSC 6188; CCRIS 7450; HSDB 906; Oxycymol; 2-Hydroxycymene; NSC-6188; EINECS 207-889-6; EPA Pesticide Chemical Code 022104; UNII-9B1J4V995Q; BRN 1860514; CHEBI:3440; AI3-03438; 9B1J4V995Q; CHEMBL281202; DTXSID6042074; 2-methyl-5-propan-2-yl-phenol; 4-06-00-03331 (Beilstein Handbook Reference); 2-Methyl-5-(1-methylethyl)-Phenol; Cymenol; Hydroxy-p-cymene; Carvacrol,(S); p-Cymene-2-ol; Carvacrol, 98%; MFCD00002236; CARVACROL [FCC]; CARVACROL [MI]; CARVACROL [FHFI]; CARVACROL [HSDB]; CARVACROL [INCI]; CARVACROL [WHO-DD]; SCHEMBL24734; 3-Isopropyl-6-methyl phenol; 3-Isopropyl-6-methyl-Phenol; BIDD:ER0492; Carvacrol, analytical standard; O-CRESOL, 5-ISOPROPYL; GTPL2497; Carvacrol, natural, 99%, FG; DTXCID4022074; Methyl-5-(1-methylethyl)phenol; p-Mentha-1,3,5-trien-2-ol; WLN: QR B1 EY1&1; FEMA 2245; NSC6188; Carvacrol, >=98%, FCC, FG; HY-N0711; Tox21_301378; BDBM50240433; s3788; STL453136; AKOS000120828; AC-2688; CCG-266210; FS-4199; LMPR0102090017; MB00118; NCGC00256001-01; CAS-499-75-2; Isothymol (=2-Isopropyl-4-methyl phenol); Carvacrol Cymenol 5-Isopropyl-2-methylphenol; CS-0009729; FT-0627526; 2-HYDROXY-4-ISOPROPYL-1-METHYLBENZENE; EN300-21426; C09840; F17722; A827907; Q225543; Carvacrol, primary pharmaceutical reference standard; W-105999; BENZENE,2-HYDROXY,4-ISOPROPYL,1-METHYL CARVACROL; F8889-1978; Z104496566; BENZENE,2-HYDROXY,4-ISOPROPYL,1-METHYL CARVACROL; InChI=1/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H; S5V

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Status
Investigative
Drug Type
Small molecular drug
Structure
Formula
C10H14O
IUPAC Name
2-methyl-5-propan-2-ylphenol
Canonical SMILES
CC1=C(C=C(C=C1)C(C)C)O
InChI
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3
InChIKey
RECUKUPTGUEGMW-UHFFFAOYSA-N
PubChem CID
10364
TTD Drug ID
D07JDC
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
 Target Info 
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Cerebral ischemia ICD-11: 8B10
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Cell Process Cell ferroptosis
In Vitro Model mHNs (Mouse hippocampal neurons)
In Vivo Model
A total of 108 gerbils (male; body weight, 70-90 g; age, 12 to 16 weeks) were used in this study. The gerbils were randomly divided into the following five groups: the vehicle-treated group (sham group),which was given an equal volume of physiological saline; the carvacrol (CAR)-treated group (CAR group); the model group, which underwent the ligation of the bilateral carotid artery for 5 min followed by the loosening of the arterial clamp for reperfusion; the model + CAR-treated groups, which included the CAR-treated group and the model + CAR-treated groups that were treated with CAR (25, 50 and 100 mg/kg/day, i.p.) for 2 consecutive weeks and the model + DFO-treated groups that were treated with DFO (150 mg/kg/day, i.p.) for 2 consecutive weeks as the positive drug group.

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Response regulation Carvacrol provides protection for hippocampal neurons against cerebral ischemia reperfusion in gerbils by inhibiting ferroptosis through increasing the expression of GPx4.
References
Ref 1 The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation. Life Sci. 2019 Oct 15;235:116795. doi: 10.1016/j.lfs.2019.116795. Epub 2019 Aug 27.