General Information of the Drug (ID: ferrodrug0014)
Name
Acetaminophen
Synonyms
acetaminophen; Paracetamol; 4-Acetamidophenol; 103-90-2; Tylenol; N-(4-Hydroxyphenyl)acetamide; APAP; Panadol; N-Acetyl-p-aminophenol; 4'-Hydroxyacetanilide; Acetaminofen; Datril; p-Hydroxyacetanilide; Algotropyl; Lonarid; Naprinol; p-Acetamidophenol; Doliprane; Injectapap; Acamol; Acenol; Anelix; Multin; p-Acetaminophenol; Abensanil; Acetagesic; Acetalgin; Biocetamol; Clixodyne; Febridol; Febrilix; Febrolin; Gelocatil; Homoolan; Liquagesic; Pyrinazine; Servigesic; Tabalgin; Tussapap; Valgesic; Vermidon; Acephen; Alpiny; Alvedon; Amadil; Anaflon; Anhiba; Apamide; Calpol; Dymadon; Eneril; Fendon; Finimal; Lestemp; Lyteca; Neopap; Pacemo; Panets; Paracet; Parmol; Tempra; Tralgon; Valadol; Dirox; Hedex; Tapar; Paracetamolo; Dafalgan; Disprol; Dolprone; Momentum; Ortensan; Paldesic; Salzone; Captin; Enelfa; Exdol; p-Acetylaminophenol; Febro-Gesic; Acetamide, N-(4-hydroxyphenyl)-; Paracetamolum; Dolgesic; Febrectal; Tempanal; Abenol; Apacet; Apadon; Banesin; Cetadol; Fensum; Janupap; Minoset; Napafen; Neodol; Nobedon; Pacemol; Panodil; Parapan; Pedric; Phendon; Rounox; Suppap; Korum; Pinex; Temlo; 4-(Acetylamino)phenol; NEBS; Acetamol; Acetofen; Aferadol; Algesidal; Apitrelal; Atralidon; Bacetamol; Ben-u-ron; Calmanticold; Causalon; Codabrol; Codalgin; Codapane; Codoliprane; Cosutone; Custodial; Deminofen; Demogripal; Desfebre; Dial-A-Gesic; Dolegrippin; Dolofugin; Doloreduct; Dolorfug; Dolorstop; Dorocoff; Dristancito; Duracetamol; Ecosetol; Elixodyne; Excipain; Fanalgic; Farmadol; Febranine; Febrectol; Febricet; Fluparmol; Geluprane; Grippostad; Gynospasmine; Infadrops; Kataprin; Magnidol; Malidens; Medocodene; Miralgin; Neodolito; Neuridon; Oxycocet; Paedialgon; Panacete; Panadeine; Panadiene; Panasorbe; Pantalgin; Paracemol; Paracenol; Paracetanol; Paracetol; Paracodol; Paradrops; Parakapton; Paralief; Paralink; Paralyoc; Paramolan; Parasedol; Paraspen; Parcetol; Pediapirin; Pediatrix; Perfalgan; Phenipirin; Phogoglandin; Pirinasol; Polmofen; Predimol; Predualito; Prontina; Pulmofen; Pyrigesic; Rubophen; Sanicopyrine; Scentalgyl; Schmerzex; Sedalito; Semolacin; Seskamol; Sinaspril; Stanback; Sunetheton; Tachiprina; Termacet; Termalgin; Termalgine; Termofren; Titralgan; Treuphadol; Tricoton; Veralgina; Abrolet; Acertol; Acetaco; Afebrin; Afebryl; Algina; Algomol; Alpinyl; Analter; Antidol; Asetam; Asomal; Asplin; Babikan; Benmyo; Cadafen; Calapol; Cefalex; Codicet; Codisal; Cofamol; Cuponol; Curadon; Curpol; Darocet; Daygrip; Democyl; Dhamol; Dolcor; Dolefin; Dolotec; Dresan; Durapan; Febrex; Febrin; Fepanil; Finiweh; Ildamol; Inalgex; Labamol; Lekadol; Lemgrip; Lemsip; Lupocet; Malgis; Maxadol; Mexalen; Minafen; Nodolex; Ofirmev; Oralgan; Paceco; Pacimol; Paedol; Panamax; Panofen; Paracin; Paracod; Parador; Parake; Paralen; Paramol; Paranox; Parasin; Parogal; Paroma; Plicet; Prodol; Puernol; Pyromed; Remedol; Rupemol; Sanicet; Scanol; Setakop; Setamol; Sifenol; Sinedol; Sinmol; Stopain; Supofen; Tazamol; Upsanol; Utragin; Verpol; Viruflu; Vivimed; Volpan; Zatinol; Zolben; Abrol; Anacin-3; Andox; Dolko; Eu-Med; Oltyl; Pacet; Pamol; Panex; Reliv; Setol; Tiffy; Tylex; Tylol; Tymol; NeoCitran; NilnOcen; Nina; RubieMol; Vips; Supadol mono; Treupel mon; Bickie-mol; Fortalidon P; Lonarid Mono; Panadeine Co; Gattaphen T; Gripin Bebe; Influbene N; Dymadon Co; Toximer P; Treupel N; 4-Acetaminophenol; Helon N; Malex N; Spalt N; Tylex CD; Paracetamole; Dimindol; Dularin; Febrinol; Nealgyl; Neotrend; Panaleve; Piramin; Rivalgyl; SK-Apap; Anapap; Aspac; Atasol; Duaneo; Duorol; Dypap; Painex; Freka-cetamol; N-Acetyl-4-aminophenol; A-Per; Junior Disprol; Kinder Finimal; Mono Praecimed; Codisal Forte; Croix Blanche; Dolorol Forte; Dymadon Forte; Kratofin simplex; Liquigesic Co; Percocet-Demi; Perdolan Mono; Rockamol Plus; Viclor Richet; Geralgine-P; Neo-Fepramol; Paracetamol AL; Paracetamol BC; Paracetamol PB; Pyregesic-C; Anti-Algos; Claradol Codeine; Melabon Infantil; Migraleve Yellow; Para-Suppo; Paracetamol Saar; Supramol-M; Fever All; No-Febril; Panado-Co; Para-Tabs; Accu-Tap; Dol-Stop; Paracetamol Hexal; Paracetamol Raffo; Paracetamol Rosch; Paracetamol Stada; Percocet-5; Acetanilide, 4'-hydroxy-; Anadin dla dzieci; Cod-Acamol Forte; Contra-Schmerz P; Medinol Paediatric; Paracetamol Basics; p-Hydroxyphenolacetamide; Panado-Co Caplets; Paracetamol von ct; Paracetamol Fecofar; Paracetamol Harkley; Paracetamol Heumann; Paracetamol Nycomed; Pe-Tam; Acetominophen; Codral Pain Relief; Aminofen; Conacetol; Darvocet; Empracet; Panasorb; Paracetamol Hanseler; Paracetamol Winthrop; Resfenol; Parelan; Phenaphen W/Codeine; Prompt; 4-Hydroxyacetanilide; Fevor; Spalt fur die nacht; A.F. Anacin; Paracetamol Genericon; Actifed Plus; Paracetamol DC; Paracetamol Ratiopharm; Dafalgan Codeine; Pasolind N; Paracetamol Italfarmaco; Paracetamol Antipanin P; St Joseph Aspirin-Free; New Cortal for Children; INFANTS' FEVERALL; p-hydroxy-acetanilid; acetaminophene; Actamin; Demilets; Efferalgan; Endecon; Flexsure; Intensin; Naldegesic; Paracetamol Dr. Schmidgall; Pasolind; Redutemp; Robigesic; Tycolet; Valorin; Allay; Norco; Acetamide, N-(p-hydroxyphenyl)-; Children's Tylenol Chewable; p-(Acetylamino)phenol; Coricidin Sinus; NCI-C55801; PCM Paracetamol Lichtenstein; Sudafed Sinus; Aceta Elixir; Quiet World; Acenol (pharmaceutical); Paracetamol SmithKline Beecham; Scherzatabletten Rezeptur 534; Co-Gesic; Tylenol (caplet); Tylenol (geltab); 4-Hydroxyanilid kyseliny octove; N-(4-Hydroxyphenyl)acetanilide; Tylenol 8-Hour; CCRIS 3; St. Joseph Fever Reducer; Midol Teen Formula; Aspirin-Free Anacin; Propacet 100; Dolene AP-65; Tylenol Allergy Sinus; St Joseph Aspirin-Free for Children; Phenol, p-acetamido-; Rhinex D-Lay Tablets; Midol Regular Strength; Children's Acetaminophen Elixir Drops; Percogesic with Codeine; Excedrin; Bayer Select Head Cold; DTXSID2020006; CHEBI:46195; HSDB 3001; p-Acetoaminophen; N-acetyl-para-aminophenol; 4-(N-Acetylamino)phenol; n-acetyl-4-hydroxyaniline; Bayer Select Allergy-Sinus; Bayer Select Headache Pain; Dristan Cold No Drowsiness; NSC-3991; EINECS 203-157-5; Prestwick_13; UNII-362O9ITL9D; 222 AF; 4-acetylaminophenol; MFCD00002328; Midol PM Night Time Formula; Tavist Allergy/Sinus/Headache; Triaminic Sore Throat Formula; N-(4-hydroxyphenyl)ethanamide; NSC 109028; NSC-109028; N-(4-hydroxyphenyl)-acetamide; 362O9ITL9D; Bayer Select Sinus Pain Relief; Sine-Off Sinus Medicine Caplets; Roxicet 5/500; Tocris-1706; Acetaminophen (4-hydroxyacetanilide); Bayer Select Menstrual Multi-Symptom; St. Joseph Cold Tablets for Children; CHEMBL112; DTXCID606; N-(4-Hydroxyphenyl)acetamide (Tylenol); Acetaminophen-13C2,15N1; NSC3991; EC 203-157-5; 4-13-00-01091 (Beilstein Handbook Reference); ALLAY COMPONENT ACETAMINOPHEN; BUCET COMPONENT ACETAMINOPHEN; component of Dialog; component of Dilone; ESGIC COMPONENT ACETAMINOPHEN; NORCO COMPONENT ACETAMINOPHEN; TRIAD COMPONENT ACETAMINOPHEN; TYLOX COMPONENT ACETAMINOPHEN; Paracetamol (INN); BANCAP COMPONENT ACETAMINOPHEN; CODRIX COMPONENT ACETAMINOPHEN; component of Endecon; FEMCET COMPONENT ACETAMINOPHEN; LORTAB COMPONENT ACETAMINOPHEN; NORCET COMPONENT ACETAMINOPHEN; OXYCET COMPONENT ACETAMINOPHEN; TENCON COMPONENT ACETAMINOPHEN; TREZIX COMPONENT ACETAMINOPHEN; ZYDONE COMPONENT ACETAMINOPHEN; NSC109028; ANEXSIA COMPONENT ACETAMINOPHEN; ANOQUAN COMPONENT ACETAMINOPHEN; BUTAPAP COMPONENT ACETAMINOPHEN; component of Percocet; HY-PHEN COMPONENT ACETAMINOPHEN; ROXICET COMPONENT ACETAMINOPHEN; ROXILOX COMPONENT ACETAMINOPHEN; SEDAPAP COMPONENT ACETAMINOPHEN; TALACEN COMPONENT ACETAMINOPHEN; TYCOLET COMPONENT ACETAMINOPHEN; VICODIN COMPONENT ACETAMINOPHEN; WYGESIC COMPONENT ACETAMINOPHEN; DARVOCET COMPONENT ACETAMINOPHEN; EXCEDRIN COMPONENT ACETAMINOPHEN; FIORICET COMPONENT ACETAMINOPHEN; PERCOCET COMPONENT ACETAMINOPHEN; TRIAPRIN COMPONENT ACETAMINOPHEN; ULTRACET COMPONENT ACETAMINOPHEN; XARTEMIS COMPONENT ACETAMINOPHEN; ACETAMINOPHEN COMPONENT OF ALLAY; ACETAMINOPHEN COMPONENT OF BUCET; ACETAMINOPHEN COMPONENT OF ESGIC; ACETAMINOPHEN COMPONENT OF NORCO; ACETAMINOPHEN COMPONENT OF TRIAD; ACETAMINOPHEN COMPONENT OF TYLOX; CO-GESIC COMPONENT ACETAMINOPHEN; component of Phenaphen; DHC PLUS COMPONENT ACETAMINOPHEN; TYL; ACETAMINOPHEN COMPONENT OF BANCAP; ACETAMINOPHEN COMPONENT OF CODRIX; ACETAMINOPHEN COMPONENT OF FEMCET; ACETAMINOPHEN COMPONENT OF LORTAB; ACETAMINOPHEN COMPONENT OF NORCET; ACETAMINOPHEN COMPONENT OF OXYCET; ACETAMINOPHEN COMPONENT OF TENCON; ACETAMINOPHEN COMPONENT OF ZYDONE; BANCAP HC COMPONENT ACETAMINOPHEN; LORCET-HD COMPONENT ACETAMINOPHEN; PHRENILIN COMPONENT ACETAMINOPHEN; component of Percogesic; NCGC00016361-07; ACETAMINOPHEN COMPONENT OF ANEXSIA; ACETAMINOPHEN COMPONENT OF ANOQUAN; ACETAMINOPHEN COMPONENT OF BUTAPAP; ACETAMINOPHEN COMPONENT OF HY-PHEN; ACETAMINOPHEN COMPONENT OF ROXICET; ACETAMINOPHEN COMPONENT OF ROXILOX; ACETAMINOPHEN COMPONENT OF SEDAPAP; ACETAMINOPHEN COMPONENT OF TALACEN; ACETAMINOPHEN COMPONENT OF TYCOLET; ACETAMINOPHEN COMPONENT OF VICODIN; ACETAMINOPHEN COMPONENT OF WYGESIC; CAS-103-90-2; ACETAMINOPHEN COMPONENT OF CO-GESIC; ACETAMINOPHEN COMPONENT OF DARVOCET; ACETAMINOPHEN COMPONENT OF DHC PLUS; ACETAMINOPHEN COMPONENT OF EXCEDRIN; ACETAMINOPHEN COMPONENT OF FIORICET; ACETAMINOPHEN COMPONENT OF PERCOCET; ACETAMINOPHEN COMPONENT OF TRIAPRIN; ACETAMINOPHEN COMPONENT OF ULTRACET; ACETAMINOPHEN COMPONENT OF XARTEMIS; ACETAMINOPHEN COMPONENT OF BANCAP HC; ACETAMINOPHEN COMPONENT OF LORCET-HD; ACETAMINOPHEN COMPONENT OF PHRENILIN; DURADYNE DHC COMPONENT ACETAMINOPHEN; DOLENE AP-65 COMPONENT ACETAMINOPHEN; DRIXORAL PLUS COMPONENT ACETAMINOPHEN; SYNALGOS-DC-A COMPONENT ACETAMINOPHEN; PARACETAMOL [INN]; MEDIGESIC PLUS COMPONENT ACETAMINOPHEN; ACETAMINOPHEN COMPONENT OF DURADYNE DHC; PARACETAMOL (IARC); PARACETAMOL [IARC]; Jin Gang; WLN: QR DMV1; ACETAMINOPHEN COMPONENT OF DOLENE AP-65; ACETAMINOPHEN COMPONENT OF DRIXORAL PLUS; ACETAMINOPHEN COMPONENT OF MEDIGESIC PLUS; ACETAMINOPHEN COMPONENT OF SYNALGOS-DC-A; PARACETAMOL (MART.); PARACETAMOL [MART.]; 8055-08-1; component of Hycomine Compound; Acetavance; Paracetamolo [Italian]; Actimol; Calonal; Genapap; Tapanol; Genebs; n-(4-hydroxyphenyl-2,3,5,6-d4)acetamide-2,2,2-d3; Drixoral Sinus; Aceta Tablets; Paracetamol [INN:BAN]; Valorin Extra; Bayer Select; Snaplets-FR; Oraphen-PD; Phenaphen Caplets; Paracetamolum [INN-Latin]; SMR000112065; Dapa X-S; Drixoral Cold & Flu; SR-01000597517; Acetaminophen [USP:JAN]; acetominophene; 4-Hydroxyanilid kyseliny octove [Czech]; Claratal; Daphalgan; Resprin; Apacet Capsules; Atasol Caplets; Atasol Tablets; Tempra Caplets; Tylenol Caplets; Tylenol Elixir; Tylenol Gelcaps; Tylenol Tablets; Actamin Extra; Actamin Super; Aminofen M

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Structure
Formula
C8H9NO2
IUPAC Name
N-(4-hydroxyphenyl)acetamide
Canonical SMILES
CC(=O)NC1=CC=C(C=C1)O
InChI
InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
InChIKey
RZVAJINKPMORJF-UHFFFAOYSA-N
PubChem CID
1983
Full List of Ferroptosis Target Related to This Drug
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Target for Ferroptosis Suppressor
Responsed Disease Sepsis ICD-11: 1G40
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model hHCs (Hippocampal cells)
HT22 cells Normal Mus musculus CVCL_0321
In Vivo Model
Healthy male C57BL/6J mice, weighing 22-24 g, 6 weeks old, were purchased from Tianyao Biotechnology Company (Tianjin, China) and housed in an environment free of specific pathogenic bacteria: temperature 22-24 , relative humidity 50%-70%, alternating day and night every 12 h, and free access to water. The cecal ligation and puncture (CLP) approach was used to establish septic mouse models. The survival rates for 7 days were determined. The Morris water maze (MWM) was utilized to assess cognitive function. Hematoxylin and eosin (HE) staining identified histopathologic alterations in hippocampal tissue.

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Response regulation In both animal and cell studies, Acetaminophen reduced iron content, ROS, glutamate antiporter (xCT), 4-hydroxy-2-nonenal (4-HNE) levels but increased GPX4 expression. Our findings suggest that APAP reduces sepsis-induced cognitive impairment by reducing ferroptosis, which is mediated by the GPX4 signaling pathway.
References
Ref 1 Acetaminophen alleviates ferroptosis in mice with sepsis-associated encephalopathy via the GPX4 pathway. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221133547. doi: 10.1177/09603271221133547.