Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0002)
Name
Boric Acid
Synonyms
BORIC ACID; Orthoboric acid; 10043-35-3; Boracic acid; Borofax; Boron hydroxide; Boron trihydroxide; Three Elephant; Basilit B; Boric acid (BH3O3); 11113-50-1; Trihydroxyborane; Trihydroxyborone; Flea Prufe; Boric acid (H3BO3); Super Flea Eliminator; Orthoborsaeure; Borsaeure; Borsaure; Orthoboric acid (B(OH)3); Optibor; Acidum boricum; NCI-C56417; Dr.'s 1 Flea Terminator DT; component of Aci-Jel; Dr.'s 1 Flea Terminator DFPBO; Dr.'s 1 Flea Terminator DF; Boric acid (VAN); Bluboro; Boricum acidum; Caswell No. 109; Dr.'s 1 Flea Terminator DTPBO; trihydroxidoboron; B(OH)3; Collyrium Eye Wash; Niban Granular Bait; CCRIS 855; NSC 81726; HSDB 1432; Ant flip; Homberg's salt; Orthoboric acid (H3BO3); EINECS 233-139-2; UNII-R57ZHV85D4; MFCD00011337; NSC-81726; Boric acid (TN); EPA Pesticide Chemical Code 011001; INS NO.284; R57ZHV85D4; CHEBI:33118; AI3-02406; INS-284; (10B)Orthoboric acid; Boric acid (h(sub 3)bo(sub 3)); H3BO3; DTXSID1020194; E-284; EC 233-139-2; [B(OH)3]; NSC81726; NCGC00090745-02; BORIC ACID (II); BORIC ACID [II]; Orthboric Acid; BORIC ACID (MART.); BORIC ACID [MART.]; Borsaure [German]; DTXCID10194; BORIC ACID (EP IMPURITY); BORIC ACID [EP IMPURITY]; BORIC ACID (EP MONOGRAPH); BORIC ACID [EP MONOGRAPH]; (B(OH)3); Kjel-sorb; Kill-off; ortho-boric acid; Boric acid [USAN:JAN]; Boric acid flakes; hydrogen orthoborate; BO3; CAS-10043-35-3; Boric acid [JAN:NF]; BORIC ACID, ACS; acido borico; Orthoborc acd; Bluboro (Salt/Mix); Boric acid ACS grade; Boric acid, Puratronic?; WLN: QBQQ; BORIC ACID [MI]; Boric acid, ACS reagent; BORIC ACID [JAN]; Heptaoxotetra-Borate(2-); bmse000941; Boric acid (JP15/NF); Boric acid (JP17/NF); BORIC ACID [INCI]; Acidum boricum (Salt/Mix); BORIC ACID [VANDF]; Boric acid, NF/USP grade; BORIC ACID [USP-RS]; BORIC ACID [WHO-DD]; Boric acid, biochemical grade; BIDD:ER0252; BORICUM ACIDUM [HPUS]; CHEMBL42403; BORIC ACID (B(OH)3); Boric acid Electrophoresis grade; Collyrium Eye Wash (Salt/Mix); BDBM39817; KGBXLFKZBHKPEV-UHFFFAOYSA-; Boric acid, 99.9% metals basis; BCP21018; Boric acid, 99.99% metals basis; Boric acid, BioXtra, >=99.5%; EINECS 237-478-7; Tox21_111004; Tox21_202185; Tox21_301000; 1332-77-0 (di-potassium salt); STL445672; Boric acid, 99.998% metals basis; AKOS015833571; Boric acid, ACS reagent, >=99.5%; DB11326; USEPA/OPP Pesticide Code: 011001; 11113-50-1;Boric acid;Boracic acid; Boric acid, 99.97% trace metals basis; Boric acid, USP, 99.5-100.5%; NCGC00090745-01; NCGC00090745-03; NCGC00090745-04; NCGC00090745-05; NCGC00254902-01; NCGC00259734-01; Boric acid, ReagentPlus(R), >=99.5%; BP-13473; Boric acid, 99.999% trace metals basis; Boric acid, SAJ first grade, >=99.5%; Boric acid, for electrophoresis, >=99.5%; Boric acid, JIS special grade, >=99.5%; Boric acid, Vetec(TM) reagent grade, 98%; FT-0623166; FT-0623167; InChI=1/BH3O3/c2-1(3)4/h2-4H; Boric acid, tablet, 1 g boric acid per tablet; D01089; A800201; Q187045; J-000132; J-523836; Boric acid, >=99.5%, suitable for amino acid analysis; Boric acid, NIST(R) SRM(R) 951a, isotopic standard; Boric acid, NIST(R) SRM(R) 973, acidimetric standard; Boric acid, BioUltra, for molecular biology, >=99.5% (T); Boric acid, United States Pharmacopeia (USP) Reference Standard; Boric acid, cell culture tested, plant cell culture tested, >=99.5%; Boric acid, Biotechnology Performance Certified, >=99.5% (titration), Cell Culture Tested; Boric acid, p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.5-100.5%; Boric acid, BioReagent, for molecular biology, suitable for cell culture, suitable for plant cell culture, >=99.5%; Boric acid, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., buffer substance, >=99.8%; Boric acid, puriss., meets analytical specification of Ph. Eur., BP, NF, 99.5-100.5%, powder

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Structure
3D MOL
2D MOL
Formula
BH3O3
IUPAC Name
boric acid
Canonical SMILES
B(O)(O)O
InChI
InChI=1S/BH3O3/c2-1(3)4/h2-4H
InChIKey
KGBXLFKZBHKPEV-UHFFFAOYSA-N
PubChem CID
7628
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 3 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Glioblastoma ICD-11: 2A00
 Disease Info 
Responsed Regulator Semaphorin-3F (SEMA3F) Driver
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell apoptosis
In Vitro Model C6 cells Malignant glioma Rattus norvegicus CVCL_0194
Response regulation Our hypothesis and results provided proof that boric acid prevent tumor progression by regulation of ferroptosis, apoptosis and semaphorin signaling pathway. BA was found to have more effective on SEMA3F/NP2 upregulated against C6 untreated cells. What's more, the novel anticancer candidate drug effect of BA were principally associated with the ACSL4/GPX4, TOS/TAS biochemical marker and SEMA3F/NP2 signaling pathways. Dose-decently BA induced oxidative and ferroptosis in Glioblastoma multiform.
Experiment 2 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Glioblastoma ICD-11: 2A00
 Disease Info 
Responsed Regulator Neuronal pentraxin-2 (NPTX2) Driver
 Regulator Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell apoptosis
In Vitro Model C6 cells Malignant glioma Rattus norvegicus CVCL_0194
Response regulation Our hypothesis and results provided proof that boric acid prevent tumor progression by regulation of ferroptosis, apoptosis and semaphorin signaling pathway. BA was found to have more effective on SEMA3F/NP2 upregulated against C6 untreated cells. What's more, the novel anticancer candidate drug effect of BA were principally associated with the ACSL4/GPX4, TOS/TAS biochemical marker and SEMA3F/NP2 signaling pathways. Dose-decently BA induced oxidative and ferroptosis Glioblastoma multiform.
Experiment 3 Reporting the Ferroptosis-centered Drug Act on This Target [2]
Responsed Disease Hepatocellular carcinoma ICD-11: 2C12
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model Hep-G2 cells Hepatoblastoma Homo sapiens CVCL_0027
Response regulation High boric acid (BA) concentrations can directly induce ferroptosis in hepatocellular carcinoma, and such BA-induced ferroptosis can add to the cytotoxic effects of anticancer drugs sorafenib, doxorubicin and cisplatin.
References
Ref 1 The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways. Environ Toxicol. 2023 Jan;38(1):70-77. doi: 10.1002/tox.23662. Epub 2022 Sep 22.
Ref 2 Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy. Biofactors. 2023 Mar;49(2):405-414. doi: 10.1002/biof.1919. Epub 2022 Dec 5.