Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00155)
| Name |
Male reproductive disorders
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| ICD |
ICD-11: VV5Z
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Full List of Target(s) of This Ferroptosis-centered Disease
Unspecific Target
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | ||||
| Responsed Disease | Male reproductive toxicity [ICD-11: VV5Z] | ||||
| Responsed Drug | Sodium arsenite | Investigative | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Ferroptosis | hsa04216 | ||||
| Cell Process | Cell ferroptosis | ||||
| In Vitro Model | GC-2spd(ts) cells | Normal | Mus musculus | CVCL_6633 | |
| In Vivo Model |
Specific pathogen free C57BL/6J male mice, aged 7 weeks old, weighted 20-24 g, were provided by Experimental Animal Center of Chongqing Medical University. The animals were adaptive feeding for a week, then randomly divided into four groups: control group, 0.5 mg/L arsenite group, 5 mg/L arsenite group and 50 mg/L arsenite group (n = 8). After exposure of arsenite via drinking water for 6 months, the animals were anesthetized, and the bilateral testicles were immediately separated on ice, weighted and calculated to get viscera coefficient.
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| Response regulation | Sodium arsenite induced oxidative stress and consequently leading to testicular cell death by ferroptosis. These findings demonstrate a potential beneficial role of supplementation of ferroptosis inhibitors for prevention or treatment of arsenite-related male reproductive toxicity. | ||||