Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00136)
| Name |
Spontaneous abortion
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|---|---|---|---|---|---|
| ICD |
ICD-11: JA00
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Full List of Target(s) of This Ferroptosis-centered Disease
Phospholipid hydroperoxide glutathione peroxidase (GPX4)
| In total 1 item(s) under this target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | |||
| Target for Ferroptosis | Suppressor | |||
| Responsed Disease | Spontaneous abortion [ICD-11: JA00] | |||
| Responsed Regulator | H19 (IncRNA) | Suppressor | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| Apoptosis | hsa04210 | |||
| Cell Process | Cell ferroptosis | |||
| Cell apoptosis | ||||
| In Vitro Model | HTR-8/SVneo cells | Normal | Homo sapiens | CVCL_7162 |
| Response regulation | Silencing H19 downregulated Bcl-2 and GPX4 expression and upregulated Bax expression at both the mRNA and protein levels in HTR-8/SVneo trophoblast cells. In conclusion, the present findings suggested that H19 has important roles in spontaneous abortion (SA) by promoting apoptosis and ferroptosis. | |||