Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00104)
| Name |
Asthma
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|---|---|---|---|---|---|
| ICD |
ICD-11: CA23
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Full List of Target(s) of This Ferroptosis-centered Disease
Unspecific Target
| In total 1 item(s) under this target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | |||
| Responsed Disease | Asthma [ICD-11: CA23] | |||
| Responsed Regulator | Interleukin-6 (IL6) | Driver | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| Cell Process | Cell ferroptosis | |||
| In Vitro Model | BEAS-2B cells | Normal | Homo sapiens | CVCL_0168 |
| Response regulation | Asthma occurs accompanied by the ferroptosis in bronchial epithelial cells, during which Interleukin-6 (IL-6) plays a key role. IL-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species (ROS)-dependent lipid peroxidation and disrupting iron homeostasis. | |||