Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00061)
| Name |
Testicular dysfunction
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| ICD |
ICD-11: 5A81
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Full List of Target(s) of This Ferroptosis-centered Disease
Heme oxygenase 1 (HMOX1)
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | ||||
| Target for Ferroptosis | Driver | ||||
| Responsed Disease | Testicular dysfunction [ICD-11: 5A81] | ||||
| Responsed Drug | Cadmium | Investigative | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Ferroptosis | hsa04216 | ||||
| Autophagy | hsa04140 | ||||
| Cell Process | Cell ferroptosis | ||||
| Cell autophagy | |||||
| In Vitro Model | TM3 cells | Normal | Mus musculus | CVCL_4326 | |
| In Vivo Model |
Eight-week-old adult male C57BL/6J mice were raised for 7 days before the study in a temperature and humidity controlled animal facility (22-25 , 50% relative humidity) with a12-h light/dark cycles. A total of 10 mice were randomly assigned into two groups. As described in our previous study, the control group was treated with 0.9% NaCl (0 mg CdCl2), and the treatment group was intraperitoneally injected with CdCl2 at a dose of 1.0 mg per kg of body weight for 1 week.
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| Response regulation | Cadmium induced ferroptosis by iron homeostasis dysregulation, mediated by excessive activation of HMOX-1. The disruption of autophagy flow contributed to Cd-induced testicular dysfunction and attenuated testosterone synthesis. | ||||