Ferroptosis-centered Disease Response Information
General Information of the Disease (ID: DIS00054)
| Name |
Anemia
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| ICD |
ICD-11: 3A9Z
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Full List of Target(s) of This Ferroptosis-centered Disease
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)
| In total 1 item(s) under this target | |||||
| Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target | [1] | ||||
| Target for Ferroptosis | Driver | ||||
| Responsed Disease | Anemia [ICD-11: 3A9Z] | ||||
| Responsed Regulator | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH) | Suppressor | |||
| Pathway Response | Fatty acid metabolism | hsa01212 | |||
| Ferroptosis | hsa04216 | ||||
| Cell Process | Cell ferroptosis | ||||
| In Vitro Model | AHH-1 cells | Normal | Homo sapiens | CVCL_3640 | |
| In Vivo Model |
4-week male C57BL/6J mice (20-22 g) were obtained from the vital river and preconditioned for one week. Mice were divided into two groups, either exposed to benzene or fresh air in the exposure system for 6 h/day, 6 days/week, for two months. In the last exposure day, the mice were fast for 10 h. Subsequently, the mice were injected with tribromoethanol (T48402, Sigma, USA) (300 mg/kg).
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| Response regulation | The iron-regulatory system IRP1, ferroptosis regulator DHODH, and fatty acids metabolism rate-limiting enzyme ALOX12 were the crucial influencers in regulating ferroptosis, this provides the potential target in attenuating benzene-induced anemia of inflammation. | ||||