Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0443)
Name
T. vulgaris and A. lappa
Drug Type
Others
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 2 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Multiple myeloma ICD-11: 2A83
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Autophagy hsa04140
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
Cell autophagy
Cell proliferation
In Vitro Model MOLP-8 cells Plasma cell myeloma Homo sapiens CVCL_2124
NCI-H929 cells Plasma cell myeloma Homo sapiens CVCL_1600
RPMI-8226 cells Plasma cell myeloma Homo sapiens CVCL_0014
KMS-12-BM cells Plasma cell myeloma Homo sapiens CVCL_1334
KMS11 cells Plasma cell myeloma Homo sapiens CVCL_2989
L-363 cells Plasma cell myeloma Homo sapiens CVCL_1357
JJN-3 cells Plasma cell myeloma Homo sapiens CVCL_2078
AMO1 cells Plasma cell myeloma Homo sapiens CVCL_1806
OPM-2 cells Plasma cell myeloma Homo sapiens CVCL_1625
NCI-H929 cells Plasma cell myeloma Homo sapiens CVCL_1600
Response regulation T. vulgaris and A. lappa could be considered as potential herbal drug candidates, which arrest multiple myeloma cancer cell proliferation by induction of apoptosis, autophagic, and ferroptosis.
Experiment 2 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Myeloid leukaemia ICD-11: 2B33
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Autophagy hsa04140
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
Cell autophagy
Cell proliferation
In Vitro Model CCRF-CEM cells T acute lymphoblastic leukemia Homo sapiens CVCL_0207
NCI-H929 cells Plasma cell myeloma Homo sapiens CVCL_1600
Response regulation T. vulgaris and A. lappa could be considered as potential herbal drug candidates, which arrest leukemia cancer cell proliferation by induction of apoptosis, autophagic, and ferroptosis.
References
Ref 1 Induction of Apoptosis, Autophagy and Ferroptosis by Thymus vulgaris and Arctium lappa Extract in Leukemia and Multiple Myeloma Cell Lines. Molecules. 2020 Oct 29;25(21):5016. doi: 10.3390/molecules25215016.