Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0415)
| Name |
Ze 450
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|---|---|---|---|---|---|
| Drug Type |
Small molecule
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Full List of Ferroptosis Target Related to This Drug
Unspecific Target
| In total 1 item(s) under this Target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Responsed Disease | Health | ICD-11: N.A. | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Gluconeogenesis | hsa00010 | |||
| Cell Process | Cell ferroptosis | |||
| In Vitro Model | HT22 cells | Normal | Mus musculus | CVCL_0321 |
| Response regulation | Ze 450 regulated HIF1 and cMyc protein levels in a shifted time dependency, which finally led to an enhanced glycolytic metabolism, by increasing HXKII and PDK1 protein levels. The protective effects against ferroptosis were mediated independently of estrogen receptor activation and were distinct from effects exerted by metformin. | |||