Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0401)
Name
Tongxinluo
Drug Type
Traditional Chinese Medicin
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Chronic obstructive pulmonary disease ICD-11: CA22
 Disease Info 
Pathway Response Glutathione metabolism hsa00480
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model hPMECs (Human pulmonary microvascular endothelial cells)
In Vivo Model
The mice were randomly divided into the following six groups (n = 10 per group): the control (CON) group, which included C57BL/6 mice that were exposed to ambient air only, fed standard rodent chow (Beijing Keao Xieli Feed Co., Ltd., Beijing, China) and perfused with 0.5% carboxymethylcellulose (CMC) sodium solution; the high-fat diet (HFD) group, which included ApoEmice that were exposed to ambient air, fed a high-fat and high-cholesterol diet and perfused with 0.5% CMC sodium solution; the CS and HFD (CS+HFD) group, which included ApoEmice that were exposed to CS in a glass box, fed a HFD, and perfused with 0.5% CMC sodium solution; theATOgroup, which included ApoEmice (exposed to CS and HFD) that were perfused with 0.01 g/kg/day ATO calcium tablets; the TXL group, which included ApoEmice (exposed to CS and HFD) that were perfused with 0.75 g/kg/day TXL ultrafine powder; and the ATO/TXL combination therapy (ATO+TXL) group, which included ApoEmice (exposed to CS and HFD) that were perfused with a combination of 0.01 g/kg/day ATO and 0.75 g/kg/day TXL.

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Response regulation Pulmonary microvascular barrier dysfunction plays an important role in chronic obstructive pulmonary disease complicated with atherosclerosis, and ferroptosis may be involved. Moreover, Tongxinluo (TXL) delays the progression of AS and reduces cardiovascular events by protecting the pulmonary microvascular barrier and inhibiting ferroptosis.
References
Ref 1 Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction. Biomed Pharmacother. 2022 Jan;145:112367. doi: 10.1016/j.biopha.2021.112367. Epub 2021 Nov 2.