Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0399)
Name
Soyauxinium chloride
Drug Type
Traditional Chinese Medicin
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 5 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Glioblastoma ICD-11: 2A00
 Disease Info 
Pathway Response Apoptosis hsa04210
Ferroptosis hsa04216
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell necroptosis
In Vitro Model AML12 cells Normal Mus musculus CVCL_0140
U-87MG cells Glioblastoma Homo sapiens CVCL_GP63
Response regulation The prominent cytotoxic potential of soyauxinium chloride (SCHL) on a panel of 18 human and animal cancer cell lines, including MDR phenotypes. This investigated indoloquinazoline alkaloid induced apoptosis in CCRF-CEM cellsviacaspases activation, MMP alteration and increase of ROS production, and caused ferroptosis and necroptosis in glioblastoma.
Experiment 2 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Myeloid leukaemia ICD-11: 2B33
 Disease Info 
Pathway Response Apoptosis hsa04210
Ferroptosis hsa04216
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell necroptosis
In Vitro Model CCRF-CEM cells T acute lymphoblastic leukemia Homo sapiens CVCL_0207
Response regulation The prominent cytotoxic potential of soyauxinium chloride (SCHL) on a panel of 18 human and animal cancer cell lines, including MDR phenotypes. This investigated indoloquinazoline alkaloid induced apoptosis in leukemia CCRF-CEM cells via caspases activation, MMP alteration and increase of ROS production, and caused ferroptosis and necroptosis.
Experiment 3 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Colon cancer ICD-11: 2B90
 Disease Info 
Pathway Response Apoptosis hsa04210
Ferroptosis hsa04216
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell necroptosis
In Vitro Model HCT 116 cells Colon carcinoma Homo sapiens CVCL_0291
CC531 cells Colon adenocarcinoma Rattus norvegicus CVCL_0206
Response regulation The prominent cytotoxic potential of soyauxinium chloride (SCHL) on a panel of 18 human and animal cancer cell lines, including MDR phenotypes. This investigated indoloquinazoline alkaloid induced apoptosis in CCRF-CEM cellsviacaspases activation, MMP alteration and increase of ROS production, and caused ferroptosis and necroptosis in colon cancer.
Experiment 4 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Melanoma ICD-11: 2C30
 Disease Info 
Pathway Response Apoptosis hsa04210
Ferroptosis hsa04216
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell necroptosis
In Vitro Model B16-F1 cells Melanoma Mus musculus CVCL_0158
B16-F10 cells Melanoma Mus musculus CVCL_0159
A2058 cells Amelanotic melanoma Homo sapiens CVCL_1059
SK-Mel 505 (Human melanoma cells)
Ma-Mel-80a cells Nodular melanoma Homo sapiens CVCL_A215
MV3 cells Amelanotic melanoma Homo sapiens CVCL_W280
SK-MEL-28 cells Cutaneous melanoma Homo sapiens CVCL_0526
Mel-2a cells Melanoma Homo sapiens CVCL_A759
Response regulation The prominent cytotoxic potential of soyauxinium chloride (SCHL) on a panel of 18 human and animal melanoma cancer cell lines, including MDR phenotypes. This investigated indoloquinazoline alkaloid induced apoptosis in CCRF-CEM cellsviacaspases activation, MMP alteration and increase of ROS production, and caused ferroptosis and necroptosis.
Experiment 5 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Breast cancer ICD-11: 2C60
 Disease Info 
Pathway Response Apoptosis hsa04210
Ferroptosis hsa04216
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell necroptosis
In Vitro Model U-87MG cells Glioblastoma Homo sapiens CVCL_0022
MDA-MB-231 cells Breast adenocarcinoma Homo sapiens CVCL_0062
Response regulation The prominent cytotoxic potential of soyauxinium chloride (SCHL) on a panel of 18 human and animal cancer cell lines, including MDR phenotypes. This investigated indoloquinazoline alkaloid induced apoptosis in CCRF-CEM cellsviacaspases activation, MMP alteration and increase of ROS production, and caused ferroptosis and necroptosis in breast cancer.
References
Ref 1 The alkaloid, soyauxinium chloride, displays remarkable cytotoxic effects towards a panel of cancer cells, inducing apoptosis, ferroptosis and necroptosis. Chem Biol Interact. 2021 Jan 5;333:109334. doi: 10.1016/j.cbi.2020.109334. Epub 2020 Nov 24.