Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0384)
Name
Indolylmaleimide derivative IM-93
Drug Type
Small molecule
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Ischemia/reperfusion injury ICD-11: DB98
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
NETosis
Response regulation The indolylmaleimide (IM) derivativeIM-17shows inhibitory activity against oxidative-stress-induced necrotic cell death and cardioprotective activity in rat ischemia-reperfusion injury models. IM-93 inhibited ferroptosis and NETosis, but not necroptosis or pyroptosis.
References
Ref 1 Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis. ACS Med Chem Lett. 2019 Jul 30;10(9):1272-1278. doi: 10.1021/acsmedchemlett.9b00142. eCollection 2019 Sep 12.