Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0383)
Name
1,1-(Decane-1,10-diyl)bis(5-fluoroindoline-2,3-dione)
Drug Type
Small molecule
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Responsed Regulator Parkinson disease protein 7 (PARK7) Suppressor
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
In Vitro Model NCI-H1299 cells Lung large cell carcinoma Homo sapiens CVCL_0060
PC-9 cells Lung adenocarcinoma Homo sapiens CVCL_B260
MDA-MB-231 cells Breast adenocarcinoma Homo sapiens CVCL_0062
HCC1937 cells Breast ductal carcinoma Homo sapiens CVCL_0290
BEL-7402 cells Endocervical adenocarcinoma Homo sapiens CVCL_5492
Hep-G2 cells Hepatoblastoma Homo sapiens CVCL_0027
786-O cells Renal cell carcinoma Homo sapiens CVCL_1051
RCC4 cells Clear cell renal cell carcinoma Homo sapiens CVCL_0498
HEK-293T cells Normal Homo sapiens CVCL_0063
In Vivo Model
Tumors were established by injecting 200 uL of H1299 cell suspensions (2 x 106) into BALB/c female athymic nude mice (5 weeks, National Rodent Laboratory Animal Resource, Shanghai, China). When the tumor volume reached an average size of 80 mm3, tumor-bearing mice were subsequently randomly divided into three groups (n = 7 for each group). STK or DM10 was intratumorally administered as a single agent in mouse tumors at a dose of 30 or 15 mg/kg only once.

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Response regulation The PARK7 gene (encode DJ-1 protein) was first discovered as an oncogene and later found to be a causative gene for autosomal recessive early onset Parkinson's disease. 1,1-(Decane-1,10-diyl)bis(5-fluoroindoline-2,3-dione) (DM10) is identified as a potent inhibitor targeting DJ-1 homodimer with the potential as sensitizing agent for other anticancer drugs.
References
Ref 1 Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors. Acta Pharmacol Sin. 2021 Jul;42(7):1160-1170. doi: 10.1038/s41401-020-00600-5. Epub 2021 Jan 25.