Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0349)
Name
Liproxstatin-1
Synonyms
Liproxstatin-1; 950455-15-9; Liproxstatin 1; N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine; N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine; N-[(3-CHLOROPHENYL)METHYL]-1'H-SPIRO[PIPERIDINE-4,2'-QUINOXALIN]-3'-AMINE; liproxstatin1; Lip-1; CHEMBL2094750; SCHEMBL17757281; EX-A558; CHEBI:173097; Liproxstatin-1, >98% (HPLC); BCP15985; DNDI1417503; MFCD14948691; s7699; AKOS001973583; CCG-175950; CS-3994; N-[(3-chlorophenyl)methyl]spiro[1,4-dihydroquinoxaline-3,4'-piperidine]-2-imine; AC-33023; BS-18273; HY-12726; EN300-202271; F17363; N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxaline]-3'-amine

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Structure
Formula
C19H21ClN4
IUPAC Name
N-[(3-chlorophenyl)methyl]spiro[1,4-dihydroquinoxaline-3,4'-piperidine]-2-imine
Canonical SMILES
C1CNCCC12C(=NCC3=CC(=CC=C3)Cl)NC4=CC=CC=C4N2
InChI
InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChIKey
YAFQFNOUYXZVPZ-UHFFFAOYSA-N
PubChem CID
135735917
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Ischemia/reperfusion injury ICD-11: DB98
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model BEAS-2B cells Normal Homo sapiens CVCL_0168
In Vivo Model
All animal procedures were approved and performed according to the protocols established by the Institutional Animal Care and Use Committee of Nanjing Medical University (approval number: 2022; June 2022). Male inbred C57BL/6J mice were purchased from Changzhou Cavans Animal Experiment Co., Ltd (Changzhou, China). Animals were housed in a temperature-controlled (22 ± 2 ) and humidity-controlled room with free access to both fresh water and standard laboratory food in Wuxi Peoples Hospital Animal Experiment Center. Ten- to 12-wk-old animals weighing 25 to 28 g were used for LTx.

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Response regulation Using liproxstatin-1 (Lip-1) to inhibit ferroptosis during CI could ameliorate LTx- cold ischemia-reperfusion injury, suggesting that Lip-1 administration might be proposed as a new strategy for organ preservation.
References
Ref 1 Liproxstatin-1 Alleviates Lung Transplantation-induced Cold Ischemia-Reperfusion Injury by Inhibiting Ferroptosis. Transplantation. 2023 May 19. doi: 10.1097/TP.0000000000004638. Online ahead of print.