General Information of the Drug (ID: ferrodrug0346)
Name
Hydnocarpin D
Synonyms
Hydnocarpin D; CHEMBL89401

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Structure
Formula
C25H20O9
IUPAC Name
5,7-dihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one
Canonical SMILES
COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4=CC(=O)C5=C(C=C(C=C5O4)O)O)CO)O
InChI
InChI=1S/C25H20O9/c1-31-20-7-13(2-4-15(20)28)25-23(11-26)32-18-5-3-12(6-21(18)34-25)19-10-17(30)24-16(29)8-14(27)9-22(24)33-19/h2-10,23,25-29H,11H2,1H3/t23-,25-/m1/s1
InChIKey
ZYWKQKQEAVWKHD-ILBGXUMGSA-N
PubChem CID
11431204
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Mature T-cell lymphoma ICD-11: 2A90
Responsed Regulator Microtubule-associated proteins 1A/1B light chain 3B {ECO:0000305} (MAP1LC3B) Driver
Pathway Response Ferroptosis hsa04216
Autophagy hsa04140
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell autophagy
Cell apoptosis
In Vitro Model Jurkat cells T acute lymphoblastic leukemia Homo sapiens CVCL_0065
MOLT4 cells Adult T acute lymphoblastic leukemia Homo sapiens CVCL_0013
CAM191 cells Normal Homo sapiens CVCL_BS93
Response regulation Using T cell acute lymphoblastic leukemia (T-ALL) cell lines Jurkat and Molt-4 as model system, Hydnocarpin D (HD) suppressed T-ALL proliferationin vitro, via induction of cell cycle arrest and subsequent apoptosis. Furthermore, HD increased the MAP1LC3B (LC3-II) levels and the formation of autophagolysosome vacuoles, both of which are markers for autophagy.
References
Ref 1 Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis. Exp Biol Med (Maywood). 2021 Jul;246(13):1541-1553. doi: 10.1177/15353702211004870. Epub 2021 Apr 29.