Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0332)
Name
Tyrosylalanine
Synonyms
tyrosylalanine; YA dipeptide; Y-A Dipeptide; Tyrosine Alanine dipeptide; Tyrosine-Alanine dipeptide; SCHEMBL238987; NLKUJNGEGZDXGO-UHFFFAOYSA-N; YA; AKOS024319161

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Structure
Formula
C12H16N2O4
IUPAC Name
2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoic acid
Canonical SMILES
CC(C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)N
InChI
InChI=1S/C12H16N2O4/c1-7(12(17)18)14-11(16)10(13)6-8-2-4-9(15)5-3-8/h2-5,7,10,15H,6,13H2,1H3,(H,14,16)(H,17,18)
InChIKey
NLKUJNGEGZDXGO-UHFFFAOYSA-N
PubChem CID
4078684
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Injury of intra-abdominal organs ICD-11: NB91
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Apoptosis hsa04210
Ferroptosis hsa04216
Necroptosis hsa04217
Cell Process Cell ferroptosis
Cell apoptosis
Cell pyroptosis
In Vitro Model mLTs (Mouse liver tissues)
In Vivo Model
Male C57BL/6 mice (7 weeks old) were purchased from Koatech Co. (Animal Breeding Center, Pyongtaek, Korea). Animals were kept on a 12 h light/dark cycle in a specific pathogen-free area with food and water freely available in the animal facility for 1 week before the experiment. All experimental animals were randomly separated into five groups as follows: Saline, LPS (1 g/kg) + D-GalN (400 mg/kg), LPS/D-GalN + YA (10 mg/kg), LPS/D-GalN + YA (50 mg/kg), and LPS/D-GalN + silymarin (25 mg/kg). YA and silymarin were pre-administered for 10 days before LPS/D-GalN by oral gavage. LPS/D-GalN was injected intraperitoneally. Blood and tissues were collected 6 h after LPS/D-GalN injection.

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Response regulation Tyrosine-alanine (YA) had a hepatoprotective effect by reducing inflammation, apoptosis, ferroptosis, and pyroptosis in the LPS/D-GalN-injected ALF mouse model. YA can be used as a functional peptide for the prevention of acute liver injury.
References
Ref 1 Oyster-Derived Tyr-Ala (YA) Peptide Prevents Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure by Suppressing Inflammatory, Apoptotic, Ferroptotic, and Pyroptotic Signals. Mar Drugs. 2021 Oct 28;19(11):614. doi: 10.3390/md19110614.