Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0331)
Name
Salicylaldehyde isonicotinoyl hydrazone
Synonyms
salicylaldehyde isonicotinoyl hydrazone; N-[(2-hydroxyphenyl)methylideneamino]pyridine-4-carboxamide; N'-[(2-HYDROXYPHENYL)METHYLIDENE]PYRIDINE-4-CARBOHYDRAZIDE; DTXSID0046272; Salinazid 100 microg/mL in Acetonitrile; CBDivE_001657; VBIZUNYMJSPHBH-UHFFFAOYSA-N; HMS2231I23; HMS3371L08; FT-0632228

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Structure
Formula
C13H11N3O2
IUPAC Name
N-[(2-hydroxyphenyl)methylideneamino]pyridine-4-carboxamide
Canonical SMILES
C1=CC=C(C(=C1)C=NNC(=O)C2=CC=NC=C2)O
InChI
InChI=1S/C13H11N3O2/c17-12-4-2-1-3-11(12)9-15-16-13(18)10-5-7-14-8-6-10/h1-9,17H,(H,16,18)
InChIKey
VBIZUNYMJSPHBH-UHFFFAOYSA-N
PubChem CID
10323
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Health ICD-11: N.A.
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vivo Model
A synchronous population was obtained by transferring egg-laying adults to fresh plates at 16 for 2-3 hr. The adults were removed and the plates with eggs then transferred to 25 to ensure sterility. After 48 hr at 25, when worms were at the late L4/young adult stage, 25-35 nematodes were transferred to fresh plates containing either vehicle control, 250 uM SIH, or 200 uM Lip-1. All plates were coded to allowing blinding of the experimenter to the treatment regime during scoring.

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Response regulation Measures of lipid peroxidation and cell death show an increase with age and reduction by both Lip-1 and salicylaldehyde isonicotinoyl hydrazone (SIH) treatment. Blocking ferroptosis, either by inhibition of lipid peroxidation or by limiting iron retention, mitigates age-related cell death and markedly increases lifespan and healthspan.
References
Ref 1 Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans. Elife. 2020 Jul 21;9:e56580. doi: 10.7554/eLife.56580.