Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0312)
Name
Dynasore
Synonyms
Dynasore; 304448-55-3; Dynamin Inhibitor I, Dynasore; CHEMBL1209885; N'-(3,4-Dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide; N'-[(3,4-dihydroxyphenyl)methylidene]-3-hydroxynaphthalene-2-carbohydrazide; N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide; Dynamin Inhibitor I; 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide; DTXSID60420841; CHEBI:132754; BDBM50323460; HB1245; MFCD00292551; s8047; STK028329; 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide; AKOS000486035; AKOS026750233; CCG-267726; CS-1340; UPCMLD0ENAT5920180:001; NCGC00386289-03; AC-32834; AS-74080; HY-15304; EC-000.2052; EN300-97658; J-017955; Z49628777; N''-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide; N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide; 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(3,4-dihydroxyphenyl)methylene]hydrazide; Dynamin Inhibitor I, Dynasore is known as a Dynamin I and Dynamin II inhibitor.; N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-3-hydroxynaphthalene-2-carbohydrazide

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Structure
Formula
C18H14N2O4
IUPAC Name
N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide
Canonical SMILES
C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O
InChI
InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChIKey
SYNDQCRDGGCQRZ-VXLYETTFSA-N
PubChem CID
135533054
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model NCI-H441 cells Lung papillary adenocarcinoma Homo sapiens CVCL_1561
A-549 cells Lung adenocarcinoma Homo sapiens CVCL_0023
NCI-H460 cells Lung large cell carcinoma Homo sapiens CVCL_0459
NCI-H727 cells Lung carcinoid tumor Homo sapiens CVCL_1584
NCI-H520 cells Lung squamous cell carcinoma Homo sapiens CVCL_1566
H332m (Human non-small cell lung cancer cells)
NCI-H82 cells Lung small cell carcinoma Homo sapiens CVCL_1591
Response regulation Dynasore can function as a highly active inhibitor of ROS-driven types of cell death via combined modulation of the iron pool and inhibition of general ROS by simultaneously blocking two routes required for ROS and lipid-ROS driven cell death in lung cancer, respectively.
References
Ref 1 Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells. 2020 Oct 9;9(10):2259. doi: 10.3390/cells9102259.