Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0247)
Name
Nuciferine
Synonyms
Nuciferine; 475-83-2; Nuciferin; Sanjoinine E; l-Nuciferine; (-)-nuciferine; (-)-Nucipherine; (R)-1,2-Dimethoxyaporphine; (R)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline; W26UEB90B7; (6ar)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline; 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (R)-; l-5,6-Dimethoxyaporphine; 1,2-Dimethoxy-6abeta-aporphine; 1-5, 6-Dimethoxyaporphine; UNII-W26UEB90B7; 6a-.beta.-Aporphine, 1,2-dimethoxy-; 6a-beta-APORPHINE, 1,2-DIMETHOXY-; (R)-NUCIFERINE; D-(-)-NUCIFERINE; CHEMBL464529; SCHEMBL20544868; DTXSID40963862; VLT 049; ORJVQPIHKOARKV-OAHLLOKOSA-N; HMS3887A19; HY-N0049; MFCD01664592; NSC785145; s3821; AKOS015903258; AC-7998; CCG-267422; CS-4270; NSC-785145; BS-42200; 1,2-DIMETHOXY-6A.BETA.-APORPHINE; N1170; A872116; Q-100504; Q7067904; 4H-DIBENZO(DE,G)QUINOLINE, 5,6,6A,7-TETRAHYDRO-1,2-DIMETHOXY-6-METHYL-, (6AR)-

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Structure
Formula
C19H21NO2
IUPAC Name
(6aR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Canonical SMILES
CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)OC)OC
InChI
InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1
InChIKey
ORJVQPIHKOARKV-OAHLLOKOSA-N
PubChem CID
10146
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Acute kidney failure ICD-11: GB60
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Glutathione metabolism hsa00480
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model HK-2 cells Normal Homo sapiens CVCL_0302
HEK-293T cells Normal Homo sapiens CVCL_0063
In Vivo Model
Male C57BL/6 mice (8-10 weeks, 20-25 g) were purchased from HuaFuKang Company (Beijing, China). After 1 week of adaptation to the housing conditions, mice were intraperitoneally injected with folic acid (250 mg/kg) to induce acute kidney injury. An injection of sodium bicarbonate (0.3-M NaHCO3, the vehicle used for folic acid treatment) alone was used as a negative control. Nuciferine (30 mg/kg) was dissolved in water, sonicated, and then immediately administered to mice intragastrically. The sham control mice were treated with nuciferine but not folic acid.

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Response regulation Nuciferine ameliorated renal injury in mice with acute kidney injury, perhaps by inhibiting the ferroptosis. Nuciferine may represent a novel treatment that improves recovery from acute kidney injury by targeting ferroptosis.
References
Ref 1 Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis. Br J Pharmacol. 2021 Mar;178(5):1182-1199. doi: 10.1111/bph.15364.