Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0239)
| Name |
Dichloroacetate
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| Synonyms |
Dichloroacetate; 2,2-dichloroacetate; Dichloracetate; 13425-80-4; Dichloroacetate ion; Dichloroacetic acid ion(1-); DCA; BRN 3903873; Ion Chromatography Standard: Dichloroacetate @ 500 microg/mL in H2O; Acetic acid, 2,?2-?dichloro-?, ion(1-?); Acetic acid, dichloro-, ion(1-) (8CI,9CI); 2,2-Dichloroacetate; Dichloroacetate anion; Dichloroacetate ion; Dichloroacetate ion(1-); 2q8h; ACETIC ACID, DICHLORO-, ION(1-); 2,2-bis(chloranyl)ethanoate; GTPL4518; CHEBI:28240; DTXSID40158610; STL483470; NCGC00241105-01; A839686; Q27077050
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| Structure |
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| Formula |
C2HCl2O2-
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| IUPAC Name |
2,2-dichloroacetate
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| Canonical SMILES |
C(C(=O)[O-])(Cl)Cl
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| InChI |
InChI=1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)/p-1
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| InChIKey |
JXTHNDFMNIQAHM-UHFFFAOYSA-M
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| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
| In total 1 item(s) under this Target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Responsed Disease | Colorectal cancer | ICD-11: 2B91 | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| Cell adhesion molecules | hsa04514 | |||
| Cell Process | Cell ferroptosis | |||
| Cell migration | ||||
| Cell stemness | ||||
| In Vitro Model | HT-29 cells | Colon adenocarcinoma | Homo sapiens | CVCL_0320 |
| HCT 116 cells | Colon carcinoma | Homo sapiens | CVCL_0291 | |
| Response regulation | Dichloroacetate (DCA) could sequester iron in lysosome and thus trigger ferroptosis, which is necessary for DCA-mediated attenuation on colorectal cancer cell stemness. And DCA can attenuate the stemness of colorectal CSCs without affecting the viability of colorectal cancer cells. | |||