Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0231)
Name
Kaempferide
Synonyms
Kaempferide; 491-54-3; Kaempferid; 4'-Methylkaempferol; 4'-O-Methylkaempferol; Kaempferol 4'-methyl ether; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one; Campheride; Kaempferol 4'-O-methyl ether; Kaemperide; Kampheride; 5,7-Dihydroxy-4'-methoxyflavonol; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-; 4'-Methoxy-3,5,7-trihydroxyflavone; NSC 407294; KAMPFERIDE; NSC-407294; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4-benzopyrone; CHEMBL40919; 508XL61MPD; CHEBI:6099; FLAVANONE, 4'-METHOXY-3,5,7-TRIHYDROXY-; NSC407294; Kempferide; 4'-Methoxykaempferol; EINECS 207-738-4; BRN 0305378; UNII-508XL61MPD; Kaemferide; Flavone, 3,5,7-trihydroxy-4'-methoxy-; Kaempferide (AS); 3 5 7-trihydroxy-4'-methoxyflavone; 3,5,7-Trihydroxy-4'-methoxyflavone; 4'-Methoxy-3',5,7-trihydroxyflavone; Kaempferol 4''-methyl ether; 5-18-05-00253 (Beilstein Handbook Reference); SCHEMBL426774; Kaempferide, analytical standard; DTXSID9034155; AMY5862; SQFSKOYWJBQGKQ-UHFFFAOYSA-N; HMS3746E09; BCP20573; BDBM50084978; LMPK12110563; MFCD00016771; s3879; Flavone,5,7-trihydroxy-4'-methoxy-; AKOS015903441; 3,5,7-Trihydroxy-4'-methoxy-Flavone; CCG-267464; CS-0957; 4'-Methoxy-3,5,7-trihydroxy-Flavanone; NCGC00379085-03; AC-30805; BS-16895; HY-15449; FT-0625213; K0057; WLN: T66 BO EVJ CR DO1& DQ GQ IQ; A827662; Q3116775; 1.3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4-benzopyrone; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one #; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,5,7-trihydroxy-2-(4-methoxyphenyl)-; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one, 9CI

    Click to Show/Hide
Status
Investigative
Drug Type
Small molecular drug
Structure
Formula
C16H12O6
IUPAC Name
3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one
Canonical SMILES
COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O
InChI
InChI=1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3
InChIKey
SQFSKOYWJBQGKQ-UHFFFAOYSA-N
PubChem CID
5281666
TTD Drug ID
D04DYO
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Nervous system disease ICD-11: 8E7Z
 Disease Info 
Pathway Response Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HT22 cells Normal Mus musculus CVCL_0321
Response regulation The ethanol extracts of Brazilian green propolis help to prevent oxidative stress-related neuronal cell death that is involved in the pathogenesis of several neurodegenerative diseases. Among the primary constituents of ethanol extracts of Brazilian green propolis, only artepillin C, kaempferide, and kaempferol demonstrated neuroprotective effects against oxytosis/ferroptosis.
References
Ref 1 Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells. Food Chem Toxicol. 2019 Oct;132:110669. doi: 10.1016/j.fct.2019.110669. Epub 2019 Jul 10.