Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0183)
Name
Dimethyl trisulfide
Synonyms
Dimethyl trisulfide; 3658-80-8; Trisulfide, dimethyl; Methyl trisulfide; DIMETHYLTRISULFIDE; 2,3,4-Trithiapentane; (methyltrisulfanyl)methane; Dimethyl trisulphide; dimethyltrisulfane; DMTS; FEMA No. 3275; CH3SSSCH3; 3E691T3NL1; NSC-97324; UNII-3E691T3NL1; Dimethyl trisufide; EINECS 222-910-9; 2,4-Trithiapentane; NSC 97324; trisulfane, dimethyl-; 1,3-Dimethyltrisulfane; AI3-26172; 1,3-Dimethyltrisulfane #; SCHEMBL446658; methylsulfanyldisulfanyl-methane; CHEBI:4614; DTXSID9063118; YWHLKYXPLRWGSE-UHFFFAOYSA-N; DIMETHYL TRISULFIDE [FHFI]; Dimethyl trisulfide, >=98%, FG; NSC97324; MFCD00039808; NSC801680; s6311; AKOS015897465; NSC-801680; 2,3,4-Trithiapentane; NSC 97324; Dimethyl trisulfide, analytical standard; BS-43830; 1,3-Dimethyltrisulfane (ACD/Name 4.0); HY-128454; CS-0099182; D3418; FT-0625104; FT-0667568; C08372; D90187; InChI=1/C2H6S3/c1-3-5-4-2/h1-2H; A823301; Q-100435; Q5277321; FLAMMABLE LIQUID, N.O.S. (DIMETHYL TRISULPHIDE)

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Structure
Formula
C2H6S3
IUPAC Name
(methyltrisulfanyl)methane
Canonical SMILES
CSSSC
InChI
InChI=1S/C2H6S3/c1-3-5-4-2/h1-2H3
InChIKey
YWHLKYXPLRWGSE-UHFFFAOYSA-N
PubChem CID
19310
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 1 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Fibrosarcoma ICD-11: 2B53
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Response regulation Diallyl trisulfide (DATS) and dimethyl trisulfide (DMTS) inhibit the erastin-induced ferroptotic cell death in fibrosarcoma HT1080 cells. Therefore, daily uptake of these ingredients in plant foods is associated with making the cells resistant to ferroptotic cell deathin vivo.
References
Ref 1 Botanical sulfane sulfur donors inhibit ferroptotic cell death caused by the depletion of cysteine. Food Chem. 2021 May 1;343:128511. doi: 10.1016/j.foodchem.2020.128511. Epub 2020 Nov 1.