Ferroptosis-centered Drug Response Information
General Information of the Drug (ID: ferrodrug0162)
| Name |
Sodium nitroprusside
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| Synonyms |
sodium nitroprusside; 13755-38-9; Sodium nitroferricyanide(III) dihydrate; Nitroprusside disodium dihydrate; DTXSID7041126; MFCD00149192; disodium;iron(4+);nitroxyl anion;pentacyanide;dihydrate; Sodium pentacyanonitrosylferrate(III) dihydrate; DTXCID5021126; CAS-13755-38-9; Nitropress (TN); Sodium nitroprusside (USP); CHEBI:9179; Na2[Fe(CN)5(NO)].2H2O; Tox21_110314; NITROPRUSSIDE SODIUM DIHYDRATE; AKOS040759055; Tox21_110314_1; Sodium nitroprusside dihydrate ACS grade; NCGC00166055-03; AC-37039; C07695; D00614; disodium pentacyano(nitroso)irondiuide dihydrate; F19620; sodium pentacyano(nitroso)ferrate(IV) dihydrate; sodium pentacyanidonitrosylferrate(2-) dihydrate; sodium pentacyanidonitrosylferrate(III) dihydrate; disodium pentacyanidonitrosylferrate--water (1/2); EN300-18543938; Sodium nitroferricyanide(III) dihydrate, ACS reagent, >=99%; Sodium nitroprusside dihydrate, Vetec(TM) reagent grade, 99%; Sodium nitroprusside dihydrate, p.a., ACS reagent, 99.0-102.0%; Sodium nitroferricyanide(III) dihydrate, JIS special grade, >=99.0%; Sodium nitroprusside, United States Pharmacopeia (USP) Reference Standard; Sodium nitroprusside dihydrate, puriss. p.a., ACS reagent, reag. Ph. Eur., >=99%; Sodium Nitroprusside, Pharmaceutical Secondary Standard; Certified Reference Material; Sodium nitroprusside dihydrate, puriss. p.a., ACS reagent, reag. Ph. Eur., Reag. Ph. Eur., >=99%
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| Structure |
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3D MOL
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| Formula |
C5H4FeN6Na2O3
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| IUPAC Name |
disodium;iron(4+);nitroxyl anion;pentacyanide;dihydrate
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| Canonical SMILES |
[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[N-]=O.O.O.[Na+].[Na+].[Fe+4]
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| InChI |
InChI=1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q5*-1;+4;-1;2*+1;;
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| InChIKey |
XRKMNJXYOFSTBE-UHFFFAOYSA-N
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| PubChem CID | |||||
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
| In total 1 item(s) under this Target | ||||
| Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target | [1] | |||
| Responsed Disease | Melanoma | ICD-11: 2C30 | ||
| Pathway Response | Fatty acid metabolism | hsa01212 | ||
| Ferroptosis | hsa04216 | |||
| MAPK signaling pathway | hsa04010 | |||
| Cell Process | Cell ferroptosis | |||
| Cell proliferation | ||||
| In Vitro Model | B16 cells | Melanoma | Mus musculus | CVCL_F936 |
| Response regulation | Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia. | |||