Ferroptosis-centered Drug Response Information

General Information of the Drug (ID: ferrodrug0026)
Name
Diallyl trisulfide
Synonyms
Diallyl trisulfide; 2050-87-5; ALLYL TRISULFIDE; Allitridin; Trisulfide, di-2-propenyl; Diallyltrisulfide; Diallyl trisulphide; allitridum; Di-2-propenyl trisulfide; diallyltrisulfane; 8008-99-9; Trisulfide, di-2-propen-1-yl; FEMA No. 3265; 3-(prop-2-enyltrisulfanyl)prop-1-ene; 1,3-Diallyltrisulfane; NSC651936; 0ZO1U5A3XX; CHEMBL123040; bis(prop-2-en-1-yl)trisulfane; DTXSID9045972; CHEBI:78492; NSC-651936; Prop-2-enyl prop-2-enylthio disulfide; NCGC00095290-01; Dasuansu; CCRIS 3251; C6H10S3; EINECS 218-107-8; UNII-0ZO1U5A3XX; NSC 651936; BRN 1745734; AI3-35127; 3-(allyltrisulfanyl)prop-1-ene; ALLITRIDE; Allyl trisulfide, 8CI; Trisulfide di-2-propenyl; 1,3-Diallyltrisulfane #; Diprop-2-en-1-yltrisulfane; (CH2=CHCH2S)2S; 0-01-00-00441 (Beilstein Handbook Reference); SCHEMBL562845; SPECTRUM1505014; DIALLYL TRISULFIDE [MI]; DTXCID7025972; FEMA 3265; 4,5,6-Trithia-1,8-nonadiene; Diallyl Trisulfide (80per cent); DIALLYL TRISULFIDE [FHFI]; UBAXRAHSPKWNCX-UHFFFAOYSA-N; Trisulfide, di-2-propenyl (9CI); DIALLYL TRISULFIDE [WHO-DD]; Tox21_111500; BDBM50318454; Diallyl trisulfide, >=97% (HPLC); Diallyl trisulfide, >=98% (HPLC); AKOS006282485; 3-(prop-2-enyltrisulfanyl)-1-propene; CCG-230978; NCGC00095290-02; AS-75640; CAS-2050-87-5; HY-117235; CS-0064491; FT-0624607; FT-0626632; A814621; Q-100252; Q17148332

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Structure
Formula
C6H10S3
IUPAC Name
3-(prop-2-enyltrisulfanyl)prop-1-ene
Canonical SMILES
C=CCSSSCC=C
InChI
InChI=1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
InChIKey
UBAXRAHSPKWNCX-UHFFFAOYSA-N
PubChem CID
16315
Full List of Ferroptosis Target Related to This Drug
Unspecific Target
In total 2 item(s) under this Target
Experiment 1 Reporting the Ferroptosis-centered Drug Act on This Target [1]
Responsed Disease Fibrosarcoma ICD-11: 2B53
 Disease Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
Cell proliferation
In Vitro Model HT-1080 cells Fibrosarcoma Homo sapiens CVCL_0317
Response regulation Diallyl trisulfide (DATS) and dimethyl trisulfide (DMTS) inhibit the erastin-induced ferroptotic cell death in fibrosarcoma HT1080 cells. Therefore, daily uptake of these ingredients in plant foods is associated with making the cells resistant to ferroptotic cell deathin vivo.
Experiment 2 Reporting the Ferroptosis-centered Drug Act on This Target [2]
Responsed Disease Prostate cancer ICD-11: 2C82
 Disease Info 
Pathway Response Ferroptosis hsa04216
Apoptosis hsa04210
Cell Process Cell ferroptosis
Cell apoptosis
Response regulation Since apoptosis resistance has been reported to be the underlying mechanism of therapy resistance in prostate cancer (PCa), Diallyl trisulfide could be used to effectively target PCa cells by overcoming apoptosis resistance and inducing ferroptosis-mediated cell death of PCa cells.
References
Ref 1 Botanical sulfane sulfur donors inhibit ferroptotic cell death caused by the depletion of cysteine. Food Chem. 2021 May 1;343:128511. doi: 10.1016/j.foodchem.2020.128511. Epub 2020 Nov 1.
Ref 2 Can diallyl trisulfide, a dietary garlic-derived compound, activate ferroptosis to overcome therapy resistance in prostate cancer?. Nutr Health. 2022 Jun;28(2):207-212. doi: 10.1177/02601060211018360. Epub 2021 May 28.