Ferroptosis-centered Disease Response Information

General Information of the Disease (ID: DIS00085)
Name
Dry eye disease
ICD
ICD-11: 9A79
Full List of Target(s) of This Ferroptosis-centered Disease
Unspecific Target
In total 1 item(s) under this target
Experiment 1 Reporting the Ferroptosis-centered Disease Response by This Target [1]
Responsed Disease Dry eye disease [ICD-11: 9A79]
Responsed Regulator Aldo-keto reductase family 1 member C1 (AKR1C1) Suppressor
 Regulator Info 
Pathway Response Fatty acid metabolism hsa01212
Ferroptosis hsa04216
Cell Process Cell ferroptosis
In Vitro Model HCE-2 cells Normal Homo sapiens CVCL_3316
In Vivo Model
A total of 72 female C57BL/6J mice aged 6 to 8 weeks were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China). The mice were injected subcutaneously with scopolamine hydrobromide (1.5 mg/0.3 mL; Sigma-Aldrich) three times daily for 5 consecutive days. Control mice matched for age and sex were maintained in an environment of 50% to 75% relative humidity.

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Response regulation Excessive oxidative stress-induced ferroptosis participates in dry eye disease (DED) pathogenesis. The expression of AKR1C1 is triggered by NRF2 to decrease ferroptosis-induced cell damage and inflammation in HCECs.
References
Ref 1 AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye. Invest Ophthalmol Vis Sci. 2022 Sep 1;63(10):3. doi: 10.1167/iovs.63.10.3.